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Patients with mastocytosis exhibit an increase in serum levels of mast cell-related mediators with exercise and therefore should be guided regarding management of mast cell-associated symptoms to improve safety and quality of life.
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http://dx.doi.org/10.1016/j.jaip.2018.07.008 | DOI Listing |
Ann Hematol
September 2025
Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria.
In a subset of patients with systemic mastocytosis (SM), an associated hematologic neoplasm (AHN) is identified. Most AHN are myeloid neoplasms, whereas lymphoid neoplasms are uncommon. We report on a 70-year-old female patient with bone marrow mastocytosis (BMM) associated with primary cutaneous follicle center lymphoma (PCFCL).
View Article and Find Full Text PDFMol Cancer Ther
September 2025
Novelty Nobility, Seongnam-si, Korea (South), Republic of.
Overexpression and gain-of-function mutations of c-Kit have been implicated in cancers including gastrointestinal stromal tumors (GIST), small cell lung cancer (SCLC), acute myeloid leukemia, and systematic mastocytosis. In clinics, small molecule c-Kit inhibitors often result in secondary c-Kit mutations or are ineffective despite c-Kit overexpression. We developed NN3201, a novel c-Kit targeting antibody-drug conjugate (ADC), via rational design to evaluate its anticancer activity in c-Kit-positive tumors, and preclinical pharmacologic profiles.
View Article and Find Full Text PDFJ Am Acad Dermatol
September 2025
Department of Medicine, Jinnah Sindh Medical University, V22W+F2H، Rafiqui H.J, Iqbal Shaheed Rd, Karachi Cantonment Karachi, Pakistan. Electronic address:
J Am Acad Dermatol
September 2025
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany; Dermato-Venereology Clinic, Karolinska University Hospital, Stockholm, Sweden; Department of Medicine (Solna), Divis
Histopathology
September 2025
Department of Pathology, University of California, San Francisco, San Francisco, California, USA.
Aims: The use of the term 'histologic eosinophilic gastritis' (EoG) has been proposed for cases with ≥30 eosinophils/high power field (HPF) in five separate HPF and with no known associated causes of eosinophilia. This study evaluates the clinical presentation, pathologic characteristics of 'histologic eosinophilic gastritis'.
Methods And Results: Gastric biopsies with prominent mucosal eosinophils over 23 years were retrieved yielding 87 qualifying cases.