Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
A great interest has been shown in the injectable scaffolds for cartilage tissue regeneration because it can fill irregularly shaped defects easily through minimally invasive surgical treatments. Herein, we developed a new injectable three-dimensional (3D) alginate hydrogel loaded with biodegradable porous poly(ε-caprolactone)--poly(ethylene glycol)--poly(ε-caprolactone) microspheres (MPs/Alg) as the calcium gluconate container to cross-link alginate. Suspensions of chondrocytes/alginate and porous microspheres turned into a gel because of the release of calcium gluconate; thus, the injectable composite hydrogels give a 3D scaffold to fit the defects perfectly and integrate the extracellular-matrix-mimicking architecture to efficiently accommodate cartilage cells in situ. Tissue repair in a full-thickness cartilage defect model was controlled at 6, 12, and 18 weeks after the implant by micro-CT and immunohistochemistry to evaluate the healing status. The defect in the MPs/Alg+ cells group achieved an almost complete repair at 18 weeks, and the repaired chondrocytes regained a normal tissue structure. Moreover, the MPs/Alg+ cells-treated group increased the quality of tissue formed, including the accumulated glycosaminoglycan and the uniformly deposited type II collagen. The results point out the promising application of the injectable MPs/Alg-chondrocytes system for cartilage tissue engineering.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044773 | PMC |
| http://dx.doi.org/10.1021/acsomega.6b00495 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A Novel Classification and Surgical Treatment Strategies for Congenital Accessory Auricle With Tragus Malformation.
J Craniofac Surg
September 2025
Department of Auricular Reconstruction, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Background: Congenital accessory auricle is a common aurcile malformation, often associated with tragus malformation, impacting the appearance and psychology of patients. To optimize surgical treatments for congenital accessory auricle with tragus malformation, this article proposes a novel classification and explores surgical strategies.
Methods: This retrospective study included 120 patients with congenital accessory auricle and tragus malformation who underwent surgery between December 2019 and June 2024.
A Guide to High-Density Porous Polyethene Ear Reconstruction.
J Craniofac Surg
September 2025
Division of Plastic and Reconstructive Surgery Medical Center, Los Angeles, CA.
Auricular reconstruction is essential for restoring facial symmetry and achieving a well-contoured, natural-appearing ear. Traditional methods using autologous costal cartilage often delay reconstruction until around age 10, when sufficient rib cartilage is available, which can pose physical and psychological challenges for pediatric patients. Porous high-density polyethylene (PHDPE) implants offer significant advantages, including the ability to perform reconstruction earlier, reduced morbidity, improved ear definition, and the possibility of a single-stage outpatient procedure.
View Article and Find Full Text PDFOne Thousand Ears in 7 years-A Single Surgeon's Experience of Performing Otoplasty and Cosmetic Ear Surgery in Adults.
J Craniofac Surg
September 2025
The Private Clinic of Harley Street, London, UK.
The majority of the literature contains outcomes of paediatric otoplasty with multiple surgeons' outcomes. However, to date, a single surgeon's case series numbering over 1000 adult cases in the same center has not been published. Cosmetic ear surgery in adults requires a completely different approach compared with children for the operating surgeon regarding assessment and technique.
View Article and Find Full Text PDFThe Long-Term Effect Investigation of Different Types of Suture and Graft Techniques on Nasal tip Projection and Rotation in Septorhinoplasty.
J Craniofac Surg
September 2025
Department of Otorhinolaryngology.
Objective: This study aimed to investigate the long-term effects of different suture and graft techniques on postoperative projection and rotation.
Methods: A total of 392 patients who met the inclusion criteria were screened and divided into 9 groups based on the technique performed. Outcome scores, tip projection ratios, and tip rotation angles were measured for the preoperative, early postoperative, and late postoperative periods.
Global Research Trends in EV-Based Cell-Free Therapy for Osteoarthritis: A Bibliometric Analysis.
Tissue Eng Regen Med
September 2025
Department of Joint and Sports Medicine, Chaoyang Central Hospital, Chaoyang City, Liaoning Province, China.
Background: Osteoarthritis (OA) represents a major global health challenge with no ideal treatment options available. Early-stage treatment typically focuses on symptomatic relief of pain and stiffness; while late-stage patients can only opt for surgical interventions such as joint replacement to improve quality of life. Cell-free therapy based on extracellular vesicles (EVs) has offered a novel therapeutic approach for regulating bone metabolism and repairing cartilage, demonstrating emerging potential.
View Article and Find Full Text PDF