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Introduction Latent tuberculosis infection (LTBI) screening with targeted treatment has been successful in eradicating tuberculosis (TB) as an endemic infection in the United States. The Centers for Disease Control and Prevention (CDC) recommends screening for high-risk patients. The aim of this study was to increase LTBI screening, detection, and treatment in our student-run free clinic while providing an innovative platform for education in primary care topics. Methods A questionnaire for screening for LTBI was adapted from CDC guidelines. Medical students and providers received education on the screening process and administered questionnaires to patients. We analyzed the rate of performed LTBI screening, the rate of diagnostic testing for patients with positive screening, and the feasibility of implementing a preventive screening initiative. Results Fifty-two patients completed primary care visits. Forty patients were screened for LTBI. Of those screened, 42.5% were positive for the screening. Of those with positive screening, 70.6% were followed up via diagnostic testing, with the rest of them being lost for follow-up due to not attending the clinic for care. Conclusions This educational intervention combined with a screening tool was effective in increasing LTBI screening rates amongst patients in a student-run free clinic.
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http://dx.doi.org/10.7759/cureus.2488 | DOI Listing |
PLoS One
September 2025
Clinical Microbiology and Parasitology Department, Hospital Universitario 12 de Octubre, Madrid, Spain.
The Quantiferon Gold Plus (QFT) test, a widely used interferon-γ release assay (IGRA), diagnoses latent tuberculosis infection (LTBI) with a positivity threshold of ≥0.35 IU/mL. Results near this cut-off can be challenging to interpret due to variability from immunological, pre-analytical, and technical factors, prompting recommendations for a borderline range to refine diagnosis and reduce overtreatment.
View Article and Find Full Text PDFIJU Case Rep
September 2025
Department of Urology Toyama University Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama Toyama Japan.
Introduction: The association between the risk of latent tuberculosis infection (LTBI) reactivation and immune checkpoint inhibitor (ICI) administration has been reported.
Case Presentation: A man in his seventies underwent robot-assisted laparoscopic radical cystectomy with ileal conduit diversion for muscle-invasive bladder cancer. Three years postoperatively, CT revealed metastases to the para-aortic lymph nodes and rectum.
Trop Med Infect Dis
August 2025
Bamrasnaradura Infectious Diseases Institute, Department of Disease Control, Ministry of Public Health, Nonthaburi 11000, Thailand.
Background: Latent tuberculosis infection (LTBI) is a major global health concern, particularly among individuals with chronic kidney disease (CKD), who are at increased risk of reactivation due to impaired immunity and frequent exposure to immunosuppressive therapies. Despite growing reliance on interferon-gamma release assays (IGRAs) such as QuantiFERON-TB Gold In-Tube (QFT-GIT) in BCG-vaccinated populations, data on IGRA performance across CKD stages remain limited in resource-limited settings.
Objective: To determine the prevalence of LTBI and indeterminate IGRA results across CKD stages in a Thai population and assess the clinical utility of IGRA in this context.
J Clin Exp Hepatol
July 2025
Institute of Digestive & Liver Diseases, BLK Superspeciality Hospital, Delhi, India.
India is a high endemic country for tuberculosis. The prevalence of tuberculosis rises in patients undergoing solid organ transplant with a high morbidity and mortality. Immunosuppressive drugs used after liver transplant have significant interactions with ATT necessitating changes in approach to treatment of tuberculosis.
View Article and Find Full Text PDFOpen Forum Infect Dis
August 2025
Division of Infectious Disease Response, Capital Regional Center for Disease Control and Prevention, Korea Disease Control and Prevention Agency, Seoul, Republic of Korea.
Background: Tuberculosis (TB) remains a significant public health concern, particularly in congregate settings such as schools, where adolescents are at increased risk transmission. This study aimed to investigate the epidemiological characteristics, transmission dynamics, and control strategies during a TB outbreak in a South Korean high school.
Methods: A retrospective epidemiological investigation was conducted using data from the Korea Tuberculosis Network and official outbreak reports.