Performance of Chlamydia trachomatis OmcB Enzyme-Linked Immunosorbent Assay in Serodiagnosis of Chlamydia trachomatis Infection in Women.

serological assays with improved sensitivity over commercially available assays are needed to evaluate the burden of infection and the effectiveness of prevention efforts. We evaluated the performance of a outer membrane complex protein B (OmcB) enzyme-linked immunosorbent assay (ELISA) in the detection of anti- antibody responses in -infected women. OmcB ELISA was less sensitive than our elementary body (EB) ELISA, but it was highly specific. The magnitude of the antibody response was higher in African-Americans and those with prior infection. Unlike EB ELISA, the IgG1 response to OmcB was short-lived and was not maintained by repeat infection.