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Objectives: With the rise of opioid use in the United States, the increasing demand for treatment for opioid use disorders presents both a challenge and an opportunity to develop new care pathways for emergency department (ED) patients seeking opioid detoxification. We set out to improve the care of patients presenting to our ED seeking opioid detoxification by implementing a standardized management pathway and to measure the effects of this intervention.
Methods: We conducted a before-after study of the effects of an opioid detoxification management pathway on ED length of stay (EDLOS), use of resources (social worker consultation, laboratory tests obtained), and return visits to the same ED within 30 days of discharge. All data were collected retrospectively by review of the electronic health record.
Results: Ultimately, 107 patients presented to the ED that met criteria, 52 in the intervention period and 55 in the preintervention period. Median EDLOS in the intervention period was 152 (interquartile range [IQR] = 93-237) minutes compared to 312 (IQR = 187-468) minutes in the preintervention period (p < 0.001). Patients in the intervention period less frequently had a social work consultation (32.7% vs. 83.6%, p < 0.001) or had laboratory tests obtained (32.7% vs 74.5%, p < 0.001) and more frequently were prescribed a medication for withdrawal symptoms (57.7% vs. 29.1%, p = 0.003).
Conclusions: Implementation of an opioid detoxification management pathway reduced EDLOS, reduced utilization of resources, and increased the proportion of patients prescribed medications for symptom relief.
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http://dx.doi.org/10.1111/acem.13457 | DOI Listing |
Acta Sci Neurol
April 2025
Division of Personalized Pain Therapy Research, Center for Advanced Spine Care of Southern Arizona, Tucson, AZ.,USA.
In spite of the ongoing exquisite work of a multitude of researchers worldwide including governmental institutions like the National Institute on Drug Abuse (NIDA) and the National Institute on Alcohol Abuse and Alcoholism (NIAAA), and for example in the United States the FDA Medication Assisted Therapy (MAT) embracing Opioid Replacement Therapy (ORT) in 2022, 111,000 people prematurely died from opioid induced overdose. It is estimated that if treatment stays as usual by 2025 the death rate will increase to 165,00.Therefore, we are encouraging the scientific and clinical community to at least consider our "out of the box" thinking whereby we are proposing a new paradigm shift involving the " dopaminergic homeostatic modeling approach and Genetic screening to early identify preaddiction.
View Article and Find Full Text PDFPLoS One
August 2025
Department of Biology, Faculty of Science, Gazi University, Ankara, Türkiye.
Background: Papaver somniferum (opium poppy) is a major source of benzylisoquinoline alkaloids (BIAs), including pharmaceutically important compounds such as morphine and noscapine. While the enzymatic pathways underlying BIA biosynthesis are well-characterized, the epigenetic mechanisms that govern tissue- and genotype-specific alkaloid accumulation remain poorly understood.
Results: This study presents a comparative DNA methylation analysis of stem and capsule tissues from P.
Toxicol Lett
August 2025
Biology Department, Faculty of Sciences, Malayer University, Malaye, Iran; Department of Biotechnology, Faculty of Interdisciplinary Sciences and Technologies, Malayer University, Malayer, Iran. Electronic address:
Methadone and morphine are two widely prescribed opioids for pain management and opioid substitution therapy. While both are pharmacologically effective, their long-term use may induce hepatotoxic effects. This study aimed to evaluate the hepatotoxic potential of methadone and morphine through an integrative approach combining experimental and bioinformatics analyses.
View Article and Find Full Text PDFJ Clin Med
July 2025
UISYS Group, Department of History of Science and Information Science, Faculty of Medicine and Dentistry, University of Valencia, 46010 Valencia, Spain.
Fentanyl plays a pivotal role in the opioid epidemic, defined by four waves of overdose deaths. To analyse fentanyl research trends, examining its links to mental health, pharmaceutical development, healthcare, diseases, and pathophysiology within the broader social and health context of the time. To understand the evolution of scientific publications on fentanyl and its relationship to the opioid crisis, a search using Web of Science Core Collection and PubMed was conducted.
View Article and Find Full Text PDFDrug Alcohol Depend
September 2025
All India Institute of Medical Sciences (AIIMS), Bhubaneswar, Odisha, India.
Background: Opioid use disorder (OUD) is a global problem with treatment involving an initial assisted withdrawal followed by maintenance phase. Methadone and buprenorphine are most commonly used agents for acute opioid withdrawal management (AOWM), but their comparative effectiveness remains uncertain. This study was aimed at comparing the efficacy and safety of oral methadone and sublingual buprenorphine for AOWM in in-patient setting.
View Article and Find Full Text PDF