Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Cryptosporidium baileyi is the most common Cryptosporidium species in birds. However, effective prevention measures and treatment for C. baileyi infection were still not available. Long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) play important roles in regulating occurrence and progression of many diseases and are identified as effective biomarkers for diagnosis and prognosis of several diseases. In the present study, the expression profiles of host mRNAs, lncRNAs and circRNAs associated with C. baileyi infection were investigated for the first time.
Results: The tracheal tissues of experimental (C. baileyi infection) and control chickens were collected for deep RNA sequencing, and 545,479,934 clean reads were obtained. Of them, 1376 novel lncRNAs were identified, including 1161 long intergenic non-coding RNAs (lincRNAs) and 215 anti-sense lncRNAs. A total of 124 lncRNAs were found to be significantly differentially expressed between the experimental and control groups. Additionally, 14,698 mRNAs and 9085 circRNAs were identified, and significantly different expressions were observed for 1317 mRNAs and 104 circRNAs between two groups. Bioinformatic analyses of gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway for their targets and source genes suggested that these dysregulated genes may be involved in the interaction between the host and C. baileyi.
Conclusions: The present study revealed the expression profiles of mRNAs, lncRNAs and circRNAs during C. baileyi infection for the first time, and sheds lights on the roles of lncRNAs and circRNAs underlying the pathogenesis of Cryptosporidium infection.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946474 | PMC |
| http://dx.doi.org/10.1186/s12864-018-4754-2 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Unveiling viral diversity and dynamics in mosquitoes through metagenomic analysis in Guizhou Province, China.
Infect Dis Poverty
June 2025
Characteristic Key Laboratory of Modern Pathogen Biology, School of Basic Medicine, Guizhou Medical University, Guiyang, 561113, Guizhou Province, People's Republic of China.
Background: Poverty, disease, and vector ecology intersect to present ongoing health threats, particularly in ecologically sensitive regions. Guizhou Province in China, with its complex karst topography and rich biodiversity, offers a unique environment to study mosquito-borne viral transmission. Despite over 5000 reported cases of Japanese encephalitis in the past two decades and the detection of Zika virus in 2016, the virological landscape of this region remains poorly understood.
View Article and Find Full Text PDFA new intermediate host of Echinococcus shiquicus in Qinghai-Tibet Plateau, China.
Parasitol Res
June 2025
State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University/National Para-Reference Laboratory for Animal Echinococcosis/Gansu Province Research Center for Basic Disciplines of Pathogen Biology/Key Laboratory of Veterinary Parasitology of Gansu
Echinococcosis is a severe parasitic zoonosis worldwide distribution, caused by the genus Echinococcus. One of its recently identified species, Echinococcus shiquicus, is believed to be endemic to the Qinghai-Tibet plateau in China. Research has confirmed that Tibetan foxes are the definitive hosts for E.
View Article and Find Full Text PDFIncidence, genetic characterization and phylogenetic analysis of Cryptosporidium species infecting domestic pigeons (Columba livia domestica) in Egypt.
Vet Parasitol Reg Stud Reports
July 2025
Department of Parasitology, Faculty of Veterinary Medicine, Cairo University, Egypt.
The current investigation was performed to study the incidence, morphological characters and molecular identification of Cryptosporidium species infecting domestic pigeons in the Giza governorate, Egypt. The incidence of Cryptosporidium spp. by modified Ziehl-Neelsen stain technique was 12 % and 14 % of the examined intestinal and bursal samples respectively.
View Article and Find Full Text PDFRed Fox () and Wolf () as a Reservoir of spp. and in Poland.
Pathogens
May 2025
Department of Eco-Epidemiology of Parasitic Diseases, Institute of Developmental Biology and Biomedical Sciences, Faculty of Biology, University of Warsaw, Miecznikowa 1, 02-096 Warsaw, Poland.
Infections with zoonotic pathogens have received increasing attention in recent years, as reflected in the literature of both veterinary and human medicine. and are recognised as the principal causes of waterborne outbreaks worldwide, but there is still limited data on the role of wild carnivores, such as red foxes and wolves, as reservoir hosts and in disseminating these pathogens in the environment. The aim of the current project was to analyse the prevalence and abundance of and infections in foxes from seven voivodeships and in wolves from the Warmia-Masuria Voivodeship in Poland and to conduct a phylogenetic analysis of the detected parasites.
View Article and Find Full Text PDFInactivation effects of slightly acidic electrolyzed water on Cryptosporidium baileyi and Eimeria tenella.
Vet Parasitol
July 2025
Key Laboratory of Animal Parasitology of Ministry of Agriculture and Rural Afairs, Laboratory of Quality and Safety Risk Assessment for Animal Products on Biohazards (Shanghai) of Ministry of Agriculture and Rural Afairs, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Scienc
Cryptosporidiosis and coccidiosis, caused by Cryptosporidium baileyi (C. baileyi) and Eimeria tenella (E. tenella), are two significant protozoan diseases affecting chicks, leading to substantial economic losses for poultry farmers.
View Article and Find Full Text PDF