Antimicrobial Activity of (Tulsi) Extract on and .

The present study was conducted with an aim to assess the antimicrobial activity of (tulsi) extract on and Tulsi extract with ethanol was prepared using cold extraction method in the present study. Various concentrations (2, 4, 6, and 8%) were then obtained by dilution with dimethylformamide. A 0.2% chlorhexidine served as the positive control, whereas the negative control was dimeth-ylformamide. Zones of inhibition were measured, each for and For comparison within the group and between the study groups, one-way analysis of variance (ANOVA) and Tukey's tests were used. A statistical significance level of p < 0.05 was established. The 8% concentration of the tulsi extract showed maximum zone of inhibition against (40.10 ± 0.90, 33.79 ± 1.82 mm), followed by the 6, 4, and 2% concentrations. The 0.2% chlorhexidine, which was the positive control, had 39.80 ± 1.24 and 32.28 ± 1.28 mm zones of inhibition; dimethylformamide showed 13.55 ± 1.92 and 10.21 ± 2.16 mm zones of inhibition against both the microorganisms. The ANOVA showed highly statistically significant (p < 0.0001) results between and within the groups. The antimicrobial activity of tulsi extract at 6 and 8% concentrations, and 0.2% chlorhexidine against showed statistically significant differences between the groups. The concentration of tulsi extract at 8 and 0.2% chlorhexidine on showed statistically significant differences between the groups. It was concluded that 8% concentration of (tulsi) extract showed the maximum antimicrobial activity against and It is thus recommended that this may be useful as an adjunc-tive to mechanical therapy in the prevention and treatment of periodontal diseases. (tulsi) is a herb that is abundantly available, easily accessible, economically feasible, and culturally acceptable. Therefore, it is very useful in the management of oral diseases and also for overcoming many barriers that exist for the utilization of dental services, such as affordability, accessibility, availability, and acceptability. Antimicrobial,