98%
921
2 minutes
20
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.4414/smw.2018.14622 | DOI Listing |
Infect Drug Resist
September 2025
Department of Emergency, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, Zhejiang, 324000, People's Republic of China.
Introduction: Severe community-acquired pneumonia (SCAP) in immunocompromised patients is often caused by rare atypical pathogens, which are difficult to detect using conventional microbiological tests (CMTs) and can progress to sepsis in severe cases. Metagenomic next-generation sequencing (mNGS), an emerging pathogen detection technique, enables rapid identification of mixed infections and provides valuable guidance for clinical treatment decisions. SCAP-induced sepsis caused by a six-pathogen co-infection has not been previously reported, but interpretation remains a challenge.
View Article and Find Full Text PDFmBio
September 2025
Department of Biology, Laboratory of Molecular Cell Biology, KU Leuven, Leuven, Flanders, Belgium.
Echinocandins, which target the fungal β-1,3-glucan synthase (Fks), are essential for treating invasive fungal infections, yet resistance is increasingly reported. While resistance typically arises through mutations in Fks hotspots, emerging evidence suggests a contributing role of changes in membrane sterol composition due to mutations. Here, we present a clinical case of () in which combined mutations in and , but not alone, appear to confer echinocandin resistance.
View Article and Find Full Text PDFCancer Pathog Ther
September 2025
Department of Microbiology, SRM Medical College Hospital and Research Centre, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu, 603203, Tamil Nadu, India.
Oral cancer pathogenesis is significantly influenced by species, especially , through chronic inflammation and cellular dysregulation. Epidemiological studies highlight a strong correlation between persistent infections and oral carcinogenesis. Experimental evidence has identified key biomolecular mechanisms, including biofilm formation, epithelial invasion, and immune evasion.
View Article and Find Full Text PDFMed Mycol Case Rep
September 2025
Albert Einstein College of Medicine and Montefiore Medical Center, 111 East 210th Street, Bronx, NY, 10467, USA.
Immunocompromised individuals are susceptible to cutaneous mycoses, often following skin trauma. Although infections by , , , , and are well-documented, human infection by unusual basidiomycetes is rarely reported. We describe a 69-year-old heart transplant recipient with a cutaneous nodule that was surgically excised and identified via fungal PCR as , a basidiomycete not previously implicated in human disease.
View Article and Find Full Text PDFCureus
September 2025
Medicine, University of Arizona College of Medicine, Phoenix, USA.
Ixekizumab, an IL-17A inhibitor, is commonly used to treat moderate-to-severe plaque psoriasis and psoriatic arthritis, with a well-documented risk of mucocutaneous infections, though its role in bacterial infections is less defined. We present the case of a 62-year-old male on ixekizumab who developed scrotal cellulitis with subsequent septic thrombophlebitis, despite no clear entry point. His condition initially improved with broad-spectrum antibiotics, but later worsened, requiring further imaging and multidisciplinary management.
View Article and Find Full Text PDF