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Capsicum annuum L. is a rich source of capsaicin, an alkaloid, which is a very pungent compound. Due to ever growing need of capsaicin, an extensive research on its efficient cultivation as well as chemical synthesis is underway. Owing to the pungent nature of capsaicin, its analogous molecules without pungent effect are being explored. The objective of this descriptive review is to comprehensively present the updates on the bioactivities of capsaicin. Additionally, the in silico target fishing approach has been used to identify the possible protein targets of capsaicin. This article will definitely provide future perspectives of research on capsaicin.
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RSC Adv
September 2025
Department of Chemistry, Central University of Karnataka Kalaburagi-585 367 Karnataka India.
This research work details the use of a molecular hybridization technique to create a library of four series of hydrazineyl-linked imidazo[1,2-]pyrimidine-thiazole derivatives. The structure of one of the final products, K2, was validated using single-crystal X-ray diffraction. Twenty-six novel hybrid molecules (K1-K26) were synthesized and tested for activity against the H37Rv strain.
View Article and Find Full Text PDFMed Phys
September 2025
Department of Accelerator and Medical Physics, National Institutes for Quantum Science and Technology (QST), Chiba, Japan.
Background: Multi-ion radiotherapy using carbon, oxygen, and neon ions aims to improve local control by increasing dose-averaged linear energy transfer (LET) in the target. However, there has been limited understanding of how to utilize variables for multi-ion treatment planning such as the selection and arrangement of ion species.
Purpose: An in silico study was conducted to explore the feasibility of increasing a minimum LET, and the optimal selection and arrangement of ion species in multi-ion therapy for increasing LET in tumors of varying sizes mimicking bone and soft tissue sarcomas (BSTS).
EMBO J
September 2025
New York University Grossman School of Medicine, Microbiology Department, New York, NY, USA.
Serine protease inhibitors (SERPINs) are involved in various physiological processes and diseases, such as inflammation, cancer metastasis, and neurodegeneration. Their role in viral infections is poorly understood, as their expression patterns during infection and the range of proteases they target have yet to be fully characterized. Here, we show widespread expression of human SERPINs in response to respiratory virus infections, both in bronchioalveolar lavages from COVID-19 patients and in polarized human airway epithelial cultures.
View Article and Find Full Text PDFChem Res Toxicol
September 2025
C.F.E.B Sisley Paris, 32 Avenue des Béthunes, 95310 Saint Ouen L'Aumône, France.
The development of alternative methods to animal testing has gained momentum over the years, including the rapid growth of methods, which are faster and more cost-effective. A large number of tools have been published, focusing on Read-Across, (quantitative) Structure-Activity Relationship ((Q)SAR) models, and Physiologically Based Pharmacokinetic (PBPK) models. All of these methods play a crucial role in the risk assessment for cosmetics.
View Article and Find Full Text PDFBioorg Chem
September 2025
Post Graduate and Research Department of Botany, A.V.V.M. Sri Pushpam College (Affiliated to Bharathidasan University), Poondi 613 503, Thanjavur, India. Electronic address:
The research employed zirconyl oxychloride as a catalyst in a reaction involving pyrazole aldehyde, (thio)urea, and acetyl acetone to establish an aqueous approach for synthesizing 3,4-dihydropyrimidinone derivatives (compounds 4a-j) with potential claims as antidiabetic agents. FT-IR, HR-MS, H NMR and C NMR were employed to analyze the synthesized compounds. The HOMO-LUMO analysis was performed to evaluate the stability of the synthesized derivatives.
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