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http://dx.doi.org/10.1097/PRS.0000000000004226 | DOI Listing |
Cancers (Basel)
July 2025
Discipline of Plastic Surgery, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Background/objectives: The aim of this case series is to evaluate the outcomes and safety of video-assisted mastectomy, illustrating the harmonious collaboration of oncologic and plastic surgery. This novel minimally invasive technique allows immediate prosthetic reconstruction and represents a cost-effective alternative to robotic breast surgery.
Methods: Video-assisted, single-port nipple-sparing mastectomies were performed in patients with small to medium-sized breasts, followed by immediate direct-to-implant reconstruction with either prepectoral or dual plane implant placement.
J Clin Med
June 2025
Hansjorg Wyss Department of Plastic Surgery, New York University Langone Health, 550 1st Ave, New York, NY 10016, USA.
Nipple-sparing mastectomy (NSM), given demonstrated oncologic safety, is widely used for both therapeutic and prophylactic mastectomy. The popularity of NSM has spurred advancements by breast and plastic surgeons, liberalizing the indications for NSM and improving patient and aesthetic reconstructive outcomes. This review explores these developments and establishes up-to-date surgical tenets for successful NSM and reconstruction.
View Article and Find Full Text PDFExpert Rev Anticancer Ther
July 2025
UOC Medical Oncology, AOUP Paolo Giaccone Palermo, Palermo, Italy.
Introduction: Breast cancer (BC) prevention in BRCA1/2 mutation carriers remains a significant clinical challenge. Risk-reducing mastectomy (RRM) is the most effective preventive option, lowering BC incidence by over 90%. Despite its survival benefit, the decision to undergo RRM is complex and shaped by psychological, social, and healthcare access factors.
View Article and Find Full Text PDFPatients with large or ptotic breasts undergoing nipple-sparing mastectomy (NSM) face reconstructive challenges, including higher risks of complications and suboptimal aesthetic outcomes. Preshaping procedures, such as mastopexy or reduction mammoplasty, have been proposed to optimize surgical outcomes by improving breast dimensions before NSM. This systematic review evaluates the safety and efficacy of these approaches.
View Article and Find Full Text PDFKeio J Med
April 2025
Department of Surgery, Keio University School of Medicine, Tokyo, Japan.
In Japan, the rising incidence of hereditary breast and ovarian cancer syndrome (HBOC) follows partial insurance coverage introduced in 2020. Compared with the general population (~11% lifetime risk), individuals with HBOC face a significantly higher lifetime risk of breast cancer (48%-76%), often presenting at younger ages. BRCA1 mutations are linked to triple-negative breast cancer, whereas BRCA2 mutations typically result in luminal-type disease.
View Article and Find Full Text PDF