98%
921
2 minutes
20
Objectives: Our primary aim was to evaluate the distribution and severity of cartilage damage in a sample of patients with scaphoid nonunion advanced collapse (SNAC), assessed on MDCT arthrography, with regard to two well-known SNAC staging systems. Secondarily, we wanted to see if the degree of cartilage damage varied with the location of the nonunion.
Methods: We retrospectively included 35 patients with a history of SNAC who had undergone MDCT arthrography. The location of the fracture was defined as the proximal, middle, or distal third of the scaphoid. Cartilage damage was assessed in 14 distinct regions of the wrist using a modified Whole-Organ Magnetic Resonance Imaging Score (WORMS) system. Staging of SNAC for each patient was based on the distribution of cartilage damage seen on MDCT arthrography. The one-way ANOVA test was used to evaluate whether global cartilage damage scores differed between patients with proximal vs middle and distal nonunion.
Results: The radial styloid-scaphoid (85.7%), the scaphoid-trapezium-trapezoid (60%), the scapho-capitate (57.1%), and the proximal radio-scaphoid joints (42.9%) were most commonly affected by degenerative cartilage damage. A substantial number of patients could not be classified according to the two SNAC staging systems. Patients with proximal nonunion exhibited a higher mean score of global cartilage damage than patients with middle or distal nonunion: 14.3 ± 9.5 (95% CI 9.8, 18.7) vs 8.6 ± 6.9 (95% CI 4.7, 12.4); p < 0.0001.
Conclusion: The distribution of cartilage damage does not always follow the pattern of progressive osteoarthritis widely described in SNAC. Proximal scaphoid nonunion is related to greater severity of global cartilage damage.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1007/s00256-018-2907-7 | DOI Listing |
Biosci Biotechnol Biochem
September 2025
Department of Orthopaedics, Xuyi People's Hospital, Kangda College of Nanjing Medical University, Huai'an, Jiangsu Province, China.
Interleukin-1β (IL-1β) is a central proinflammatory cytokine implicated in osteoarthritis (OA), but its precise role in chondrocyte apoptosis remains to be fully elucidated. In this study, we demonstrate that IL-1β triggers mitophagy in chondrocytes by promoting Parkin translocation and p62 recruitment to damaged mitochondria, thereby reducing mitochondrial dysfunction and apoptosis. Loss of p62 resulted in impaired mitophagy, excessive mitochondrial superoxide accumulation, and increased cell death.
View Article and Find Full Text PDFVet Surg
September 2025
Clinic for Small Animals, University of Veterinary Medicine Hannover, Hannover, Germany.
Objective: To describe and compare arthroscopy-assisted (AA) with fluoroscopy-assisted (FA) minimally invasive plate osteosynthesis (MIPO) for simple transverse acetabular fractures.
Study Design: Ex vivo cadaveric study.
Sample Population: A total of 10 canine cadavers (>20 kg) without coxofemoral joint disease.
Stem Cells Int
August 2025
R&D Center, Wuhan Hamilton Biotechnology Co. Ltd, Wuhan, Hubei, China.
Osteoarthritis (OA) is the leading joint disease that causes joint pain and disability. Despite increasing progress regarding the therapeutic potential of human umbilical cord mesenchymal stem cells (UC-MSCs) for OA, effective strategies for the treatment of OA using UC-MSCs have not yet been developed in clinical practice. Our present study has proven that the early stage in OA rats is the main development stage of nod-like receptor heat protein domain protein 3 (NLRP3)-mediated synovial inflammation.
View Article and Find Full Text PDFDrug Des Devel Ther
September 2025
The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, 310053, People's Republic of China.
Purpose: To assess the pharmacodynamic effects and therapeutic mechanisms of modified Fuzi decoction (MFZD) in osteoarthritis (OA), particularly OA-related inflammation.
Methods: The main components of MFZD were identified using Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry (UPLC-MS/MS). An OA model was established in Sprague-Dawley rats via intra-articular injection of monoiodoacetate (MIA) to evaluate the anti-OA efficacy of MFZD via gavage.
JBJS Essent Surg Tech
September 2025
Division of Hand and Reconstructive Microsurgery, Department of Orthopedics, Olympia Hospital & Research Centre, Trichy, Tamilnadu, India.
Background: Hemi-hamate osteochondral grafting is a surgical technique that is utilized to reconstruct the proximal interphalangeal (PIP) joint in cases of unstable dorsal fracture-dislocation with >50% articular surface involvement. However, hemi-hamate osteochondral grafting can be technically challenging, has been reported to have various technical modifications, and can lead to complications such as overstuffing of the joint. This surgical technique article describes successful PIP joint reconstruction with use of a hemi-capitate osteochondral graft, which may offer a viable alternative to hemi-hamate osteochondral graft.
View Article and Find Full Text PDF