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Article Abstract
An asymmetric synthesis of a 3'-deoxy-3'-F-fluorothymidine (F-FLT) precursor has been developed wherein the deoxysugar moiety was synthesized using a novel Ga-mediated allylation of (R)-2,3-cyclohexylideneglyceraldehyde as the key step. The synthesis deviates significantly from the previous syntheses of the F-FLT precursors wherein the expensive starting material, thymidine was used.
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| http://dx.doi.org/10.1016/j.ejmech.2017.10.047 | DOI Listing |
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