Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Triterpenes constitute a large and important class of plant natural products with diverse structures and functions. Their biological roles range from membrane structural components over plant hormones to specialized plant defence compounds. Furthermore, triterpenes have great potential for a variety of commercial applications such as vaccine adjuvants, anti-cancer drugs, food supplements and agronomic agents. Their biosynthesis is carried out through complicated, branched pathways by multiple enzyme types that include oxidosqualene cyclases, cytochrome P450s, and UDP-glycosyltransferases. Given that the number of characterized triterpene biosynthesis enzymes has been growing fast recently, the need for a database specifically focusing on triterpene enzymology became eminent. Here, we present the TriForC database (http://bioinformatics.psb.ugent.be/triforc/), encompassing a comprehensive catalogue of triterpene biosynthesis enzymes. This highly interlinked database serves as a user-friendly access point to versatile data sets of enzyme and compound features, enabling the scanning of a complete catalogue of experimentally validated triterpene enzymes, their substrates and products, as well as the pathways they constitute in various plant species. The database can be accessed by direct browsing or through convenient search tools including keyword, BLAST, plant species and substructure options. This database will facilitate gene mining and creating genetic toolboxes for triterpene synthetic biology.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753214 | PMC |
| http://dx.doi.org/10.1093/nar/gkx925 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Bioconversion of glycyrrhizin in a natural intensive sweetener by immobilized β-glucuronidase.
Food Res Int
November 2025
Department of Agriculture and Forest Sciences (DAFNE), Tuscia University, via S. Camillo de Lellis snc, 01100 Viterbo, Italy.
The demand for natural sweeteners as alternatives to sucrose is growing rapidly, driving research into enzymatic bioconversion methods for more efficient production. Glycyrrhizin (GL) is approximately 190 times sweeter than sucrose, but its excessive consumption has been linked to adverse health effects. Its hydrolysis yields glycyrrhetic acid 3-O-mono-β-D-glucuronide (GAMG), a compound nearly 1000 times sweeter than sucrose and with improved sensory and solubility properties.
View Article and Find Full Text PDFBlack soldier fly (Hermetia illucens) larvae accumulate bioactive compounds that modulate antioxidant activity when reared with bioactive agrifood by-products.
Food Res Int
November 2025
Sección Departamental de Ciencias de la Alimentación. Facultad de Ciencias. Universidad Autónoma de Madrid, 28049 Madrid, Spain; Departamento de Producción y Caracterización de Nuevos Alimentos. Instituto de Investigación en Ciencias de la Alimentación (CIAL) (CSIC-UAM), 28049 Madrid, Spain.
The effect of feeding Hermetia illucens larvae (black soldier fly, BSFL) with by-products from olive oil (dry olive leaves, OL; full-fat dry olive pomace, OP) or quinoa (quinoa husk, QH) on the bioaccumulation of bioactive compounds and antioxidant activity of the meals was evaluated. Diets were formulated with different percentages of inclusion (OL15, OL30, OL50; OP30, OP50, OP70, OP90; QH15, QH30, QH50). Antioxidant activity (DPPH and ABTS methods), total phenolic compounds (TPC), targeted bioactive compounds analysis, and estimation of efficiency of bioaccumulation (EB) were performed, and compared to the experimental substrates.
View Article and Find Full Text PDFFunctional analysis of Sf-NPF1 in food intake and antifeedant induction by azadirachtin in Spodoptera frugiperda larvae.
Pestic Biochem Physiol
November 2025
State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Guangdong Provincial Key Laboratory of Plant Molecular Breeding, South China Agricultural University, Guangzhou 510642, China. Electronic address:
Azadirachtin, a highly effective botanical pesticide, demonstrated notable biological activities against Spodoptera frugiperda, including mortality induction, growth and development inhibition, and antifeedant effects. Neuropeptide F (NPF) has been shown to play a role in various physiological processes in insects. Nonetheless, the functions of Sf-NPF1 in regulating food intake and antifeedant induction by azadirachtin in S.
View Article and Find Full Text PDFGlycyrrhizic acid: novel potential protein targets.
Biomed Khim
September 2025
Institute of Biomedical Chemistry, Moscow, Russia.
To date, a large body of data has been accumulated on the biological activity of a low-toxic natural glycoside, glycyrrhizic acid (GA), but the mechanism of its action at the molecular level has not been fully studied. Expanding knowledge about the spectrum of cellular protein targets of GA contributes to understanding new features of pharmacodynamics. The aim of the work was the experimental identification of a tissue-specific spectrum of protein molecules interacting with GA in a model system.
View Article and Find Full Text PDFThe antiadipogenic effect of the pentacyclic triterpenoid isoarborinol is mediated by LKB1-AMPK activation.
PLoS One
September 2025
Instituto Politécnico Nacional, Escuela Nacional de Medicina y Homeopatía, Laboratorio de Biomedicina Molecular 2, México City, México.
Obesity and overweight are two highly prevalent conditions worldwide, which can lead to death or produce chronic and degenerative diseases. The search for alternative therapies to control these morbidities can involve the study of metabolites obtained from plants. Particularly, pentacyclic triterpenes produce an antiadipogenic effect by affecting the expression of master regulators of adipogenesis and their signaling pathways, including LKB1-AMPK pathway.
View Article and Find Full Text PDF