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Summary: Proteins frequently function as parts of complexes, assemblages of multiple proteins and other biomolecules, yet network visualizations usually only show proteins as parts of binary interactions. ComplexViewer visualizes interactions with more than two participants and thereby avoids the need to first expand these into multiple binary interactions. Furthermore, if binding regions between molecules are known then these can be displayed in the context of the larger complex.
Availability And Implementation: freely available under Apache version 2 license; EMBL-EBI Complex Portal: http://www.ebi.ac.uk/complexportal; Source code: https://github.com/MICommunity/ComplexViewer; Package: https://www.npmjs.com/package/complexviewer; http://biojs.io/d/complexviewer. Language: JavaScript; Web technology: Scalable Vector Graphics; Libraries: D3.js.
Contact: colin.combe@ed.ac.uk or juri.rappsilber@ed.ac.uk.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870653 | PMC |
http://dx.doi.org/10.1093/bioinformatics/btx497 | DOI Listing |
Nat Sci Sleep
September 2025
Department of Ophthalmology, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, People's Republic of China.
Objective: To investigate the prevalence of dry eye disease (DED) among children and adolescents aged 9 to 19 years in Fengyang County, and to explore the associations of sleep duration and social jetlag with DED, with the aim of providing scientific evidence for sleep-based interventions to prevent DED in this population.
Methods: Between November and December 2023, 14 primary and secondary schools were randomly selected in Fengyang County, Chuzhou City, Anhui Province, China. Students from Grade 4 to Grade 12 (aged 9-19 years) were invited to participate.
Front Endocrinol (Lausanne)
September 2025
Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
Objective: This study aimed to investigate comorbidity patterns and potential pathogenic mechanisms in patients with Hashimoto's thyroiditis (HT).
Methods: Patients with HT who visited the outpatient clinic of the Thyroid Department at Dongzhimen Hospital, Beijing University of Chinese Medicine, between June 2021 and December 2024 were included. Association rule analysis and logistic regression analysis were performed using SPSS 25.
Front Psychiatry
August 2025
Department of Psychiatry, Nagoya City University East Medical Center, Nagoya, Japan.
Although post-earthquake psychological distress arises from a complex interplay of personal vulnerabilities and environmental stressors, the pathways by which these factors interact remain underexplored. We surveyed 327 hospital nurses in Nanao City, Japan, approximately eight months after the magnitude-7.5 2024 Noto Peninsula earthquake; 224 complete responses were analyzed.
View Article and Find Full Text PDFChem Sci
August 2025
Inorganic Solid State Chemistry, Saarland University Campus C4.1 66123 Saarbrücken Germany
Intermetallic compounds belong to an important class of materials, not only due to the sheer number of compounds known but also due to their application in everyday life. These compounds possess their very own peculiarities, especially when it comes to chemical bonding. To address this point, bonding analyses based on Crystal Orbital Bond Index (COBI) values, Löwdin charges, and - for the first time - oxidation numbers (ON ) were conducted, all extracted from delocalized plane-wave functions.
View Article and Find Full Text PDFNanoscale Horiz
September 2025
School of Biomedical Engineering, University of Sydney, Darlington 2008, New South Wales, Australia.
Entropy-driven drying-mediated self-assembly of plasmonic nanocrystals (termed "plasmonic atoms") has emerged as a general strategy for fabricating plasmene nanosheets from a wide range of monodisperse nanocrystals. However, extending this approach to binary systems remains challenging due to the complex nanoscale interactions between dissimilar nanocrystal shapes. Here, we introduce a combined enthalpy- and entropy-driven strategy to achieve an orderly mixed two-dimensional (2D) binary nanoassemblies from complementary reacting polymer-ligated nanocrystals.
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