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Article Abstract
Altered glucose reabsorption the facilitative glucose transporter 2 (GLUT2) during diabetes may lead to renal proximal tubule cell (RPTC) injury, inflammation, and interstitial fibrosis. These pathologies are also triggered by activating the cannabinoid-1 receptor (CBR), which contributes to the development of diabetic nephropathy (DN). However, the link between CBR and GLUT2 remains to be determined. Here, we show that chronic peripheral CBR blockade or genetically inactivating CBRs in the RPTCs ameliorated diabetes-induced renal structural and functional changes, kidney inflammation, and tubulointerstitial fibrosis in mice. Inhibition of CBR also downregulated GLUT2 expression, affected the dynamic translocation of GLUT2 to the brush border membrane of RPTCs, and reduced glucose reabsorption. Thus, targeting peripheral CBR or inhibiting GLUT2 dynamics in RPTCs has the potential to treat and ameliorate DN. These findings may support the rationale for the clinical testing of peripherally restricted CBR antagonists or the development of novel renal-specific GLUT2 inhibitors against DN.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791066 | PMC |
| http://dx.doi.org/10.1681/ASN.2017040371 | DOI Listing |
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