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Background: Omega-3 fatty acids (n3 FA) promote beneficial effects on cardiovascular diseases, but they are highly susceptible to oxidation, which leads to the formation of potentially toxic secondary products. In this study, the antioxidant capacity of natural compounds (sinapic acid and rutin) was evaluated using an accelerated model to oxidize the oils. Five inducers (temperature, Fe , 2,2'-azobis(2-amidinopropane) dihydrochloride, ascorbyl palmitate and the hydrophobic 2,2'-azobis-2,4-dimethylvaleronitrile (AMVN)) were combined in a factorial design to accelerate the oxidation of three oils (flaxseed, echium and fish) containing different sources of n3 FA.
Results: Lipid hydroperoxide (LOOH) and thiobarbituric acid reactive substance (TBARS) concentrations estimated using the regression models did not differ from the observed values. AMVN + Fe increased TBARS in all samples.
Conclusion: The values for the oxidative markers obtained 48 h after induction were similar to those obtained when the oils were heated at 60 ° C for 15 days. Of a number of volatile compounds formed from the oxidation of different n3 FA sources, (E,E)-2,4-heptadienal, (E,E)-2,4-decadienal, decanal, undecanal and (E)-2-undecenal were identified in all samples and could be used as more specific oxidative markers. Using the accelerated model, rutin improved the oxidative stability of fish oil, probably due to the presence of a catechol group in its chemical structure. © 2017 Society of Chemical Industry.
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http://dx.doi.org/10.1002/jsfa.8739 | DOI Listing |
Folia Microbiol (Praha)
September 2025
Soil Science Division, Bangladesh Wheat and Maize Research Institute, Dinajpur, 5200, Bangladesh.
The aim of the study was to reduce the chemical fertilizers with microbial inoculant-rich vermicompost, which enhanced the growth, flowering, and soil health of the tuberose crop. A total of six treatments were applied with reducing doses of synthetic fertilizers under a factorial randomized design and replicated thrice. In this study, vermicompost (VC) made from cow dung and vegetable waste utilizing Eisenia foetida and their mixed biomass were enriched with microbial inoculants and assessed for their impact on microbial and enzymatic populations including urease, acid phosphatase activity and dehydrogenase activity in soil, nutrient availability, and tuberose development and flowering.
View Article and Find Full Text PDFFood Res Int
November 2025
Ciência e Tecnologia de Alimentos, Centro de Ciências Agrárias, Universidade Estadual de Londrina, Celso Garcia Cid, PR-445, Km 380 - University Campus, Londrina, PR 86057-970, Brazil. Electronic address:
The objective of the research was to employ extrusion to increase the yield of simulated gastrointestinal digestion of protein corn gluten meal (CG). A single-screw extruder and a full factorial design with two center points were used. The optimal extrusion parameters were 40 % sample moisture, 140 °C and 54 rpm, resulting in a gastrointestinal digestion yield of 37.
View Article and Find Full Text PDFAquac Nutr
August 2025
Department of Biotechnology, Persian Gulf Research Institute, Persian Gulf University, Bushehr, Iran.
A 60-day research was conducted to evaluate the influence of dietary fish oil (FO) and selenium nanoparticles (SeNPs) on performance of juveniles (2.4 ± 0.0 g) reared in seawater (SW) or hypersaline (HS) water conditions.
View Article and Find Full Text PDFStat Med
September 2025
Division of Biostatistics, Department of Population Health, New York University Grossman School of Medicine, New York, New York, USA.
Factorial study designs can be important for understanding the effectiveness of interventions when multiple interventions are under investigation. In this design setting, a unit of randomization can be assigned to any combination of interventions. The rationale for taking this kind of approach can vary depending on the specific questions targeted by the research.
View Article and Find Full Text PDFJ Pharm Sci
September 2025
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, The British University in Egypt, Cairo, Egypt.
Bacterial burn wound infections can disrupt the natural wound-healing process, leading to life-threatening diseases. This study aimed to investigate the use of glycerosomes as a novel system for the topical delivery of cefoperazone to promote its burn wound healing action. Cefoperazone-loaded glycerosomes (CEFO-GLY) were optimized using a 2 full-factorial design and prepared via the thin film hydration method.
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