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Article Abstract
Three-component coupling of Fischer carbene complexes, enyne aldehyde hydrazones, and electron-deficient alkynes leads to simple benzoate derivatives in a process involving the formation of an N-aminopyrrole derivative, Diels-Alder reaction, and nitrene extrusion. The products are readily converted into isoquinolones through reaction with primary amines. The reaction proceeds best with highly substituted and electron-rich pyrroles even though these are the sterically least favorable substrates, and this reactivity trend is supported by a computational study.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5619673 | PMC |
| http://dx.doi.org/10.1016/j.tetlet.2017.02.070 | DOI Listing |
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