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Sporadic cases of diphtheria are very rare throughout Europe. A 3-year-old incompletely vaccinated girl was admitted with pharyngotonsillitis caused by diphtheria. On day 9 of her illness, renal and cardiac failure with a third-degree AV-block occurred. Unfortunately, she died within 36 h of admission to intensive care, despite pacemaker placement, the administration of antibiotics and diphtheria antitoxin. The delayed antitoxin administration 7 days after admission to hospital was related to a lack of availability and knowledge of its availability in Europe and this is likely to have contributed to the unfavourable outcome.
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http://dx.doi.org/10.1080/20469047.2017.1378796 | DOI Listing |
J Biol Chem
August 2025
Department of Chemistry and Biochemistry, University of California, Los Angeles, 611 Charles E. Young Drive East, Los Angeles, CA 90095, USA; UCLA-DOE Institute of Genomics and Proteomics, University of California, Los Angeles, 611 Charles E. Young Drive East, Los Angeles, CA 90095, USA; Molecular B
Corynebacterium diphtheriae causes diphtheria, a potentially fatal infectious disease that damages tissues in the upper respiratory tract. In order to proliferate, this pathogen acquires the essential nutrient iron from heme (iron-protoporphyrin IX) primarily found in human hemoglobin (Hb). C.
View Article and Find Full Text PDFFront Epidemiol
July 2025
WHO Country Office, N'djamena, Chad.
Background: The escalation of the conflict in Sudan has created a major humanitarian challenge for neighboring countries, especially in the Eastern regions of Chad. This humanitarian setting's health needs are unique in that they are more vulnerable to both outbreak-prone disease and a lack of essential services. To address these challenges, the World Health Organization has supported implementing the Early Warning Alert and Response System (EWARS) Mobile.
View Article and Find Full Text PDFEBioMedicine
August 2025
Department of Epidemiology & Population Health, Kano Independent Research Centre Trust, Nigeria. Electronic address:
Background: The COVID 19 pandemic led to significant disruptions in health services, including immunisation programs, which contributed to a major post-pandemic diphtheria outbreak in Kano State, Nigeria. This region accounted for 85% of the nation's documented diphtheria cases.
Methods: This study examined the epidemiology, clinical characteristics, and mortality outcomes of cases diagnosed between February 2022 and April 2024.
Infect Dis Now
September 2025
Dermatology Department, A. Paré University Hospital, Boulogne Billancourt, France.
Introduction: Cutaneous diphtheria typically develops on preexisting skin lesions and presents as painful, well-defined ulcers covered by false membranes or as exudate, usually on the limbs.
Patients And Methods: We report on six cases of cutaneous diphtheria recently diagnosed in France. Diagnosis was confirmed through microbiological testing of skin swabs, which identifiedCorynebacterium diphtheriae non-toxigenic strains.
Cureus
May 2025
Department of Pediatrics, Cliniques universitaires Saint-Luc, Brussels, BEL.
Diphtheria is primarily a childhood disease that has become rare in Europe. It is caused by bacteria and typically presents in two main clinical forms: respiratory and cutaneous. With timely treatment using antibiotics and anti-diphtheria serum, serious complications and deaths remain uncommon.
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