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With the growth of 3D packaging technology and the development of flexible, transparent electrodes, the use of multilayer thin-films is steadily increasing throughout high-tech industries including semiconductor, flat panel display, and solar photovoltaic industries. Also, this in turn leads to an increase in industrial demands for inspection of internal analysis. However, there still remain many technical limitations to overcome for measurement of the internal structure of the specimen without damage. In this paper, we propose an innovative optical inspection technique for simultaneous measurements of the surface and film thickness corresponding to each layer of multilayer film structures by computing the phase and reflectance over a wide range of wavelengths. For verification of our proposed method, the sample specimen of multilayer films was fabricated via photolithography process, and the surface profile and film thickness of each layer were measured by two different techniques of a stylus profilometer and an ellipsometer, respectively. Comparison results shows that our proposed technique enables simultaneous measurements of the top surface and its underlying film surfaces with high precision, which could not be measured by conventional non-destructive methods.
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http://dx.doi.org/10.1038/s41598-017-11825-6 | DOI Listing |
J Proteome Res
September 2025
Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington 98195, United States.
Retinol binding protein 4 (RBP4), the circulating carrier of retinol, complexes with transthyretin (TTR) and is a potential biomarker of cardiometabolic disease. However, RBP4 quantitation relies on immunoassays and Western blots without retinol and TTR measurement. A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the simultaneous absolute quantitation of circulating RBP4 and TTR is critical to establishing their biomarker potential.
View Article and Find Full Text PDFJ Chem Ecol
September 2025
Leibniz Institute for Vegetable and Ornamental Crops (IGZ) e.V., Großbeeren, Germany.
Plant roots are exposed to various organisms that significantly impact plant productivity. Plant-parasitic nematodes (PPNs) such as Meloidogyne spp. and Pratylenchus spp.
View Article and Find Full Text PDFJ Magn Reson Imaging
September 2025
Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Background: Carotid artery stenosis is a major cause of stroke. Non-contrast MR angiography (MRA) using time-spatial labeling inversion pulse (Time-SLIP) may offer potential advantages over 3D time-of-flight (TOF)-MRA for simultaneous visualization of carotid, vertebral, and subclavian arteries, but remains uninvestigated.
Purpose: To determine optimal black blood inversion time (TI) for visualizing the carotid and subclavian arteries using three-dimensional (3D) fast field echo (FFE) Time-SLIP MRA, and to compare its image quality with 3D TOF-MRA.
Rev Sci Instrum
September 2025
LAPLACE, Université de Toulouse, CNRS, INPT, UPS, 118 route de Narbonne, 31062 Toulouse, France.
A two-axis thrust stand is developed and validated experimentally, enabling direct and simultaneous measurements of two components of the thrust vector of an electric thruster. It is made of two piled-up single-axis stages, each having a hanging deformable parallelogram geometry. A mass deposition calibration method is used to calibrate the thrust stand, including crosstalk between axes.
View Article and Find Full Text PDFJ Acoust Soc Am
September 2025
Key Laboratory of Modern Acoustics, Institute of Acoustics, Nanjing University, Nanjing 210093, China.
Rectangular horns are widely used in professional audio applications, but designing horns with desired radiation efficiency and directivity is time-consuming and often relies on empirical methods. A multimodal-based optimization approach is proposed in this study and can simultaneously improve the radiation efficiency and directivity control of rectangular horns over a wide frequency range. Based on acoustical properties accurately simulated by a discrete model, the terms in the objective function are constructed to measure radiation efficiency, penalize jagged shapes, and improve directivity control.
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