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http://dx.doi.org/10.5603/KP.2017.0156 | DOI Listing |
Magn Reson Med
September 2025
Department of Integrative Bioscience and Biomedical Engineering, Graduate School of Advanced Science and Engineering, Waseda University, Tokyo, Japan.
Purpose: This study investigated the effect of bicuspid aortic valve (BAV) morphology and ascending aortic curvature (AAAc) bending angles on aortic hemodynamics, focusing on transvalvular jets and secondary helical flows that contribute to systolic hemodynamic stress linked to aortic complications.
Methods: Using an MRI-compatible pulsatile flow and pressure system, 24 configurations involving six aortic valves (three Type 1 asymmetric BAVs, two Type 0 symmetric BAVs, and one tricuspid aortic valve [TAV]) across four ascending aortic morphologies-two diameters (30 mm and 40 mm) and two AAAc angles (130° and 109°)-were analyzed through four-dimensional-flow MRI measurements.
Results: Three Type 1 BAVs displayed highly deviated transvalvular jets directed toward the aortic wall on the side of the nonfused cusp.
Echocardiography
September 2025
Department of Radiology, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Purpose: Identifying factors associated with left ventricular (LV) remodeling is important for risk stratification of patients with moderate aortic stenosis (AS). The aim of this preliminary study was to explore aortic hemodynamics in these patients and assess their relationships with LV remodeling using four-dimensional (4D) flow magnetic resonance imaging (MRI).
Method: Data from 17 patients with moderate AS involving the tricuspid aortic valves and normal LV ejection fraction (EF > 55%) were analyzed.
Bioengineering (Basel)
July 2025
Department of Radiology, Northwestern University, Chicago, IL 60611, USA.
Four-dimensional (4D) flow MRI has shown promise for the assessment of aortic hemodynamics. However, data analysis traditionally requires manual and time-consuming human input at several stages. This limits reproducibility and affects analysis workflows, such that large-cohort 4D flow studies are lacking.
View Article and Find Full Text PDFRadiol Cardiothorac Imaging
August 2025
Department of Radiology, Feinberg School of Medicine, Northwestern University; 737 N Michigan Ave, Ste 1600, Chicago, IL 60611.
Four-dimensional (4D) flow MRI has emerged as a versatile technique for the three-dimensional evaluation of blood flow dynamics, offering the ability to visualize flow patterns qualitatively and allow for the retrospective quantification of standard and advanced hemodynamic parameters. Recent advancements in 4D flow MRI technology, including optimized acquisition protocols and improved hemodynamic analysis workflow efficiency, have facilitated its integration into standard clinical practice, enhancing the accessibility and applicability of this innovative imaging modality. A growing body of studies have demonstrated its clinical value for monitoring and informing the management of aortic pathologies, cementing its role in modern cardiovascular care.
View Article and Find Full Text PDFJ Magn Reson Imaging
August 2025
Division of Diagnostics and Specialist Medicine, Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.
Background: Valvular heart disease (VHD) commonly leads to the development of turbulent blood flow. Turbulent kinetic energy (TKE), measured with 4D flow MRI, may be a complement to current metrics for early identification of VHD.
Purpose: To investigate TKE as a marker of VHD in relation to flow velocity and cardiovascular geometry.