Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Two new dioxomorpholines, 1 and 2, three new derivatives, 3-5, and the known compound PF1233 B (6) were isolated from a marine-facultative Aspergillus sp. MEXU 27854. Their structures were established by 1D and 2D NMR and HRESIMS data analysis. The absolute configuration of 1 and 2 was elucidated by comparison of experimental and DFT-calculated vibrational circular dichroism spectra. Compounds 3, 5, and 6 were noncytotoxic to a panel of human cancer cell lines with different functional status for the tumor-suppressor protein p53, but were inhibitors of P-glycoprotein-reversing multidrug resistance in a doxorubicin-resistant cell line.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.jnatprod.7b00331 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Genome Mining and Molecular Networking-Based Metabolomics of the Marine Facultative sp. MEXU 27854.
Molecules
September 2021
Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México 04510, Mexico.
The marine-facultative sp. MEXU 27854, isolated from the Caleta Bay in Acapulco, Guerrero, Mexico, has provided an interesting diversity of secondary metabolites, including a series of rare dioxomorpholines, peptides, and butyrolactones. Here, we report on the genomic data, which consists of 11 contigs (N50~3.
View Article and Find Full Text PDFMetabolites from the Marine-Facultative sp. MEXU 27854 and MEXU 29901 from Caleta Bay, Mexico.
Tetrahedron Lett
June 2019
Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México 04510, México.
During our ongoing research on fungal strains from unexplored sources, the reinvestigation of the CHCl-MeOH extract of the marine-facultative sp. MEXU 27854 yielded a new -methyl cyclic pentapeptide () along with known butyrolactone II and PF1233 A. In addition, from the marine-facultative MEXU 29901, a new alternariol glucoside, 10-[-D-(4-methoxyl-glucopyranosyl)]-4--methylalternariol () and known alternariol 4-methyl ether, alternariol and beauvericin, were isolated.
View Article and Find Full Text PDFDioxomorpholines and Derivatives from a Marine-Facultative Aspergillus Species.
J Nat Prod
August 2017
Departamento de Química, Centro de Investigación y de Estudios, Avanzados del Instituto Politécnico Nacional , Apartado 14-740, Ciudad de México 07000, México.
Article Synopsis
- Two new compounds, dioxomorpholines 1 and 2, along with three derivatives (3-5) and the known compound PF1233 B (6), were extracted from a marine Aspergillus species.
- The structural identification of these compounds was achieved using advanced NMR and HRESIMS techniques, with the absolute configuration of 1 and 2 determined through vibrational circular dichroism spectra analysis.
- While compounds 3, 5, and 6 showed no toxicity to various human cancer cell lines, they were effective in inhibiting P-glycoprotein, which helps counteract multidrug resistance, particularly in doxorubicin-resistant cells.