Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
The influence of two anxiolytics--diazepam and buspirone--on prolactin, thyrotrophin and cortisol levels in green monkey (Cercopithecus aethiops) plasma was studied 30 min following i/m injection. Diazepam at 1 mg/kg decreased prolactin and cortisol levels by 30-50% compared to the control animals. Buspirone at 2.5-10 mg/kg induced a 7-10-fold increase in prolactin level but did not change cortisol and thyrotrophin concentration. Buspirone analog--Mj 138-05 at 10 mg/kg produced a 2-3-fold increase in plasma prolactin content in some animals, while at a dose of 5 mg/kg it exerted no detectable effect. Possible neurochemical mechanisms of the effects observed are discussed.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Diagnosis of Cushing's syndrome in a guinea pig (Cavia porcellus) applying the modified version of the low-dose dexamethasone-suppression test used in canines.
Acta Vet Hung
September 2025
4Department of Internal Medicine, University of Veterinary Medicine Budapest, István Street 2, 1078 Budapest, Hungary.
The low dose dexamethasone stimulation test (LDDST) is routinely used in canine medicine but in the few cases in guinea pigs diagnosed with hypercortisolism, the adrenocorticotropic hormone (ACTH) stimulation test was used. The objective of the authors was to conduct a pilot study and find out if the standard test used in dogs can be used in this species.A 4-year-old intact female hairless guinea pig showed bilaterally enlarged adrenal glands and high cortisol levels.
View Article and Find Full Text PDFLong-term Outcomes And Survival Predictors In Patients With Ectopic ACTH Syndrome: Data From A Retrospective Cohort Study.
Endocr Connect
September 2025
Department of Clinical Endocrinology, Endocrinology Research Centre, Moscow, Russia.
Background: Ectopic ACTH syndrome (EAS) is caused by non-pituitary neuroendocrine tumor (NET) which produces adrenocorticotropic hormone (ACTH).
Objective: To identify survival predictors and to analyze long-term outcomes in patients with EAS.
Methods: Medical records of patients with verified EAS between 1990 and 2024 were analyzed to obtain the initial clinical and biochemical data along with subsequent interventions and survival outcomes.
To Evaluate the Effect of Pediatric Massage Combined with Comprehensive Management on Growth Parameters and Biochemical Indicators in Children with Short Stature.
Int J Gen Med
August 2025
Department of Pediatrics, Fujian Medical University Union Hospital, Fujian, 350000, People's Republic of China.
Purpose: To investigated the effect of pediatric massage combined with comprehensive management on height improvement in children with short stature.
Patients And Methods: This retrospective analysis included medical records of 80 children diagnosed with short stature, who received treatment at Wuhu Hospital of Traditional Chinese Medicine between April 2022 and April 2023. According to the recorded treatment modalities, patients were divided into two groups: the control group received standard comprehensive management (including psychological health guidance, diet, sleep, exercise), while the massage group received additional pediatric syndrome-based massage therapy alongside comprehensive treatment.
Post-viral alterations in periodontal health in individuals recovering from COVID-19.
Front Oral Health
August 2025
Department of Periodontology, Faculty of Dental Medicine, University of Belgrade, Belgrade, Serbia.
This study explores post-viral immune modulation in periodontal health using COVID-19 convalescence as a model. We hypothesized that post-COVID-19 recovery induces epigenetic alterations, measurable through salivary methyl-transferase-like 3 (METTL3) expression and clinical-periodontal parameters. The present research comprises results from two studies: the clinical study, which included a total of 83 systemically healthy adults stratified into four groups according to periodontal status and COVID-19 history, and the laboratory study on human parotid gland samples ( = 10).
View Article and Find Full Text PDFAdrenal Insufficiency after Steroid Therapy in Children with Steroid-Sensitive Nephrotic Syndrome: A Cross-sectional Study.
Indian J Endocrinol Metab
August 2025
Department of Pediatrics, Endocrinology and Metabolism, University College of Medical Sciences and Guru Teg Bahadur Hospital, New Delhi, India.
Introduction: Glucocorticoid-induced adrenal insufficiency (AI) is underestimated and under-reported in children with nephrotic syndrome (NS). This study aimed to estimate the prevalence of AI in children with steroid-sensitive NS, defined by serum cortisol level <18 mcg/dL 30 minutes after low-dose adrenocorticotropin stimulation test (LDST) and/or baseline (8 AM) serum cortisol level <5 mcg/dL, 4-12 weeks after stopping steroid therapy.
Methods: In this cross-sectional study, 73 children with steroid-sensitive NS, in remission and off steroids for 4-12 weeks, were enrolled from the Paediatrics Department at a tertiary care hospital.