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Article Abstract
The purpose of this work was to study the anatomic and metabolic changes that occur with tumor progression, regression and recurrence in a switchable MYC-driven murine breast cancer model. Serial H MRI and hyperpolarized [1-C]pyruvate metabolic imaging were used to investigate the changes in tumor volume and glycolytic metabolism over time during the multistage tumorigenesis. We show that acute de-induction of MYC expression in established tumors results in rapid tumor regression and significantly reduced glycolytic metabolism as measured by pyruvate-to-lactate conversion. Moreover, cancer recurrences occurring at the tumor sites independently of MYC expression were observed to accompany markedly increased lactate production.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632580 | PMC |
| http://dx.doi.org/10.1016/j.mri.2017.07.014 | DOI Listing |
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