Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
The current study used diffusion tensor imaging to examine patterns/degree of brain connectivity in 12 college-aged binge drinking (BD) and 12 moderate drinking individuals. Voxel-level and region-of-interest analyses revealed increased connectivity of the BD brain in the right corona radiata, right external capsule, and both the right and left cingulum. Also, fractional anisotropy and axial diffusivity values of these regions correlated with a number of drinking behaviors of the BD as well as both groups combined. It is hypothesized that increased connectivity in the BD may produce difficulties with regulatory control, contributing to their propensity to binge.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/13554794.2017.1347264 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Genetically modeled GLP1R and GIPR agonism reduce binge drinking and alcohol-associated phenotypes: a multi-ancestry drug-target Mendelian randomization study.
Mol Psychiatry
September 2025
Section on Clinical Genomics and Experimental Therapeutics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.
Pharmacological modulation of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) through dual GIP/GLP-1 receptor agonists, commonly used for diabetes and obesity, shows promise in reducing alcohol consumption. We applied drug-target Mendelian randomization (MR) using genetic variation at these loci to assess their long-term effects on problematic alcohol use (PAU), binge drinking, alcohol misuse classifications, liver health, and other substance use behaviors. Genetic proxies for lowered BMI, modeling the appetite-suppressing and weight-reducing effects of variants in both the GIPR and GLP1R loci ("GIPR/GLP1R"), were linked with reduced binge drinking in the primary (β = -0.
View Article and Find Full Text PDFSwiss Webster mice as a model for excessive alcohol binge drinking consumption.
Methods Cell Biol
September 2025
LR18ES03 Laboratory of Neurophysiology, Cellular Physiopathology and Valorisation of Biomolecules, Faculty of Science of Tunis, University Tunis El Manar, Tunis, Tunisia. Electronic address:
Binge drinking (BD) is a widespread pattern of excessive alcohol consumption among adolescents and young adults with detrimental consequences for brain development. Animal models are essential for investigating the neurobiological mechanisms underlying BD, but selecting an appropriate model is critical to ensure relevance to human behavior. This study aims to validate a murine model of (BD) using Swiss Webster mice.
View Article and Find Full Text PDFTesting the efficacy and mechanisms of an SMS intervention focused on motivating peer network support to reduce alcohol consumption in non-collegiate young adults: Protocol for a randomized trial.
Contemp Clin Trials
September 2025
Quantitative Sciences Unit, Stanford School of Medicine, United States of America.
Background: Non-collegiate young adults engage in high rates of heavy drinking but are less likely to access alcohol-related counseling or treatment. Peers play a significant role in shaping drinking behavior, yet few interventions target close peer influence in this population.
Methods: This two-arm randomized controlled trial will enroll 300 young adults aged 18-25 who report 2+ heavy drinking days (HDD; defined as 4+ drinks for a woman and 5+ drinks for a man) in the past 30 days and are not enrolled in college.
Disentangling the effects of corticotrophin releasing factor and GABA release from the bed nucleus of the stria terminalis on ethanol self-administration in mice.
Neuropsychopharmacology
September 2025
Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Excessive alcohol use causes a great deal of harm and negative health outcomes. Corticotrophin releasing factor (CRF), a stress-related neuropeptide, has been implicated in binge ethanol intake and ethanol dependence in rodents. CRF containing neurons in the bed nucleus of the stria terminalis (BNST) can influence ethanol consumption.
View Article and Find Full Text PDFAlcohol use and mental health distress correlates among artisanal gold miners in Ghana.
Int J Drug Policy
September 2025
Department of Geography and Rural Development, Kwame Nkrumah University of Science and Technology, KNUST, P. O. Box Up 1279 AK-447-9691, Kumasi, Ghana.
Despite rising concerns about alcohol use in artisanal mining, a focused investigation into its psychosocial drivers and mental health implications within sub-Saharan Africa's informal mining sector remains scarce. This study investigates the prevalence, motivations, and the association between alcohol use and mental health outcomes (depression, anxiety, and stress) among artisanal miners in Ghana. Using community based cross-sectional survey data from 664 miners, alcohol use was assessed using the Alcohol Use Disorders Identification Test, while symptoms of anxiety, stress, and depression were measured via the GAD-7, PSS, and PHQ-9 instruments.
View Article and Find Full Text PDF