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Article Abstract
A new synthetic protocol provides a simple and direct method to generate functionalized β-hydroxy-tetrahydroquinolines (THQs). Hydroboration of quinolines using chloroboranes followed by oxidation with NaBO ⋅H O led to the formation of functionalized β-hydroxy THQs. High regio- and diastereoselectivities were observed in α and γ substituted quinolines and the trans diastereomer of the β-hydroxy-THQ was the major isostere. This new protocol was utilized to build the novel antibody-targeted lupus peptidomimetic, FISLE-412.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003427 | PMC |
| http://dx.doi.org/10.1002/chem.201701944 | DOI Listing |
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