The RIP3-RIP1-NF-κB signaling axis is dispensable for necroptotic cells to elicit cross-priming of CD8 T cells.

Cell Mol Immunol

State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen Fujian 361005, China.

Published: July 2017


Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590049PMC
http://dx.doi.org/10.1038/cmi.2017.31DOI Listing

Publication Analysis

Top Keywords

rip3-rip1-nf-κb signaling
4
signaling axis
4
axis dispensable
4
dispensable necroptotic
4
necroptotic cells
4
cells elicit
4
elicit cross-priming
4
cross-priming cd8
4
cd8 cells
4
cells
2

Similar Publications

Background: Genetic modifiers are believed to play an important role in the onset and severity of polycystic kidney disease (PKD), but identifying these modifiers has been challenging due to the lack of effective methodologies.

Methods: We generated zebrafish mutants of IFT140, a skeletal ciliopathy gene and newly identified autosomal dominant PKD (ADPKD) gene, to examine skeletal development and kidney cyst formation in larval and juvenile mutants. Additionally, we utilized ift140 crispants, generated through efficient microhomology-mediated end joining (MMEJ)-based genome editing, to compare phenotypes with mutants and conduct a pilot genetic modifier screen.

View Article and Find Full Text PDF

Spinal muscular atrophy (SMA) is a neuromuscular disease caused by low levels of SMN protein. Several therapeutic approaches boosting SMN are approved for human patients, delivering remarkable improvements in lifespan and symptoms. However, emerging phenotypes, including neurodevelopmental comorbidities, are being reported in some treated SMA patients, indicative of alterations in brain development.

View Article and Find Full Text PDF

Cardiac hypertrophy is a common adaptation to cardiovascular stress and often a prelude to heart failure. We examined how S-palmitoylation of the small GTPase, Ras-related C3 botulinum toxin substrate 1 (Rac1), impacts cardiomyocyte stress signaling. Mutation of the cysteine-178 palmitoylation site impaired activation of Rac1 when overexpressed in cardiomyocytes.

View Article and Find Full Text PDF

Common neural choice signals reflect accumulated evidence, not confidence.

Cereb Cortex

August 2025

Brain and Cognition, KU Leuven, Tiensestraat 102, 3000 Leuven, Belgium.

Centro-parietal electroencephalogram signals (centro-parietal positivity and error positivity) correlate with the reported level of confidence. According to recent computational work these signals reflect evidence which feeds into the computation of confidence, not directly confidence. To test this prediction, we causally manipulated prior beliefs to selectively affect confidence, while leaving objective task performance unaffected.

View Article and Find Full Text PDF

Neural stem cells (NSCs) are multipotent stem cells with self-renewal capacity, able to differentiate into all neural lineages of the central nervous system, including neurons, oligodendrocytes, and astrocytes; thus, their proliferation and differentiation are essential for embryonic neurodevelopment and adult brain homoeostasis. Dysregulation in these processes is implicated in neurological disorders, highlighting the need to elucidate how NSCs proliferate and differentiate to clarify the mechanisms of neurogenesis and uncover potential therapeutic targets. MicroRNAs (miRNAs) are small, post-transcriptional regulators of gene expression involved in many aspects of nervous system development and function.

View Article and Find Full Text PDF