Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: To mimic the muscle inspired cells adhesion through proteins secretion, the lamination of collagen-hydroxyapatite nanorod (nHA) composite nanofibers has been carried out successfully on polydopamine (PDA)-coated microfibrous polylactide-co-glycolide (PLGA) fabrics. The lamination of collagen-hydroxyapatite composite nanofibers on polydopamine-coated microfibrous PLGA fabrics was carried through electrospinning the solution of collagen containing L-glutamic acid-grafted hydroxyapatite nanorods (nHA-GA) at a flow rate of 1.5 mL/h and an applied voltage of 15 kV.
Results: In comparison to pristine PLGA, dopamine-coated PLGA and collagen-hydroxyapatite composite nanofiber lamination has produced more wettable surfaces and surface wettability is found to higher with dopamine-coated PLGA fabrics then pristine PLGA. The SEM micrographs have clearly indicated that the lamination of polydopamine-coated PLGA fabric with collagen-hydroxyapatite composite nanofibers has shown increased adhesion of MC3T3E1 cells in comparison to pristine PLGA fabrics.
Conclusion: The results of these studies have clearly demonstrated that collagen-nHA composites fibers may be used to create bioactive 3D scaffolds using PLGA as an architectural support agent.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470256 | PMC |
| http://dx.doi.org/10.1186/s40824-017-0097-3 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Localized Combination Therapy Using Collagen-Hydroxyapatite Bone Grafts for Simultaneous Bone Cancer Inhibition and Tissue Regeneration.
Polymers (Basel)
August 2025
Institute of Cellular Biology and Pathology "Nicolae Simionescu", 8 B. P. Hasdeu Street, District 5, 050568 Bucharest, Romania.
The global burden of cancer continues to grow, with bone cancer-though rare-posing serious challenges in terms of treatment and post-surgical reconstruction. Autologous bone grafting remains the gold standard, yet limitations such as donor site morbidity drive the search for alternative solutions. Tissue engineering, combining biomaterials and therapeutic agents, offers promising avenues.
View Article and Find Full Text PDFCollagen/Hydroxyapatite Hydrogels Promote Intercellular Interactions and Osteogenic Differentiation.
J Biomed Mater Res B Appl Biomater
August 2025
Department of Convergence Biosystems Engineering, Chonnam National University, Gwangju, Republic of Korea.
Bone defects resulting from trauma, disease, or congenital abnormalities present formidable clinical challenges, necessitating advanced regenerative strategies. In this study, a novel bone tissue engineering approach utilizing the osteoinductive properties of collagen/hydroxyapatite (HA) hydrogels and the structural support provided by 3D-printed polylactic acid (PLA) scaffolds was investigated. Specifically, MG63 osteoblast-like cells were encapsulated within collagen/HA hydrogels formulated at an optimized 5:5 ratio and subsequently loaded into PLA lattices.
View Article and Find Full Text PDFA Collagen Membrane Pretreated with Citrate Promotes Collagen Mineralization and Bone Regeneration.
J Funct Biomater
July 2025
Hospital of Stomatology, Sun Yat-sen University, Guangzhou 510055, China.
Collagen membranes with biomimetic mineralization are emerging as promising materials for bone regeneration, owing to their high biocompatibility. In this study, we developed a biogenic collagen membrane by combining citrate (C) pretreatment and carboxymethyl chitosan (CMC)-mediated mineralization and further evaluated its bone healing potential. C-CMC collagen membranes were prepared by lyophilization.
View Article and Find Full Text PDFAdvancing atom probe tomography capabilities to understand bone microstructures at near-atomic scale.
Acta Biomater
May 2025
Max-Planck-Institute for Sustainable Materials, Max-Planck-Str. 1, Düsseldorf 40237, Germany; Department of Materials, Imperial College London, London SW7 2AZ, UK. Electronic address:
Bone structure is generally hierarchically organized into organic (collagen, proteins, ...
View Article and Find Full Text PDFThe Role of Crosslinking Agents in the Development of Collagen-Hydroxyapatite Composite Materials for Bone Tissue Engineering.
Materials (Basel)
February 2025
Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology POLITEHNICA Bucharest, Gh. Polizu 1-7, 011061 Bucharest, Romania.
The lack of bone grafts represents a major issue in the orthopedic field, reconstructive surgery, and dentistry. There are several bone conditions that often demand the use of grafts, such as fractures, infections, and bone cancer. The number of bone cancer cases increased in the past few decades and along with it, the need for bone grafting materials.
View Article and Find Full Text PDF