98%
921
2 minutes
20
Background: Controversy exists regarding the optimal lead position for chronic right ventricular (RV) pacing. Placing a lead at the RV septum relies upon fluoroscopy assisted by a surface 12-lead electrocardiogram (ECG). We compared the postimplant lead position determined by ECG-gated multidetector contrast-enhanced computed tomography (MDCT) with the position derived from the surface 12-lead ECG.
Methods: Eighteen patients with permanent RV leads were prospectively enrolled. Leads were placed in the RV septum (RVS) in 10 and the RV apex (RVA) in eight using fluoroscopy with anteroposterior and left anterior oblique 30° views. All patients underwent MDCT imaging and paced ECG analysis. ECG criteria were: QRS duration; QRS axis; positive or negative net QRS amplitude in leads I, aVL, V1, and V6; presence of notching in the inferior leads; and transition point in precordial leads at or after V4.
Results: Of the 10 leads implanted in the RVS, computed tomography (CT) imaging revealed seven to be at the anterior RV wall, two at the anteroseptal junction, and one in the true septum. For the eight RVA leads, four were anterior, two septal, and two anteroseptal. All leads implanted in the RVS met at least one ECG criteria (median 3, range 1-6). However, no criteria were specific for septal position as judged by MDCT. Mean QRS duration was 160 ± 24 ms in the RVS group compared with 168 ± 14 ms for RVA pacing (P = 0.38).
Conclusions: We conclude that the surface ECG is not sufficiently accurate to determine RV septal lead tip position compared to cardiac CT.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1111/pace.13066 | DOI Listing |
Urol Oncol
September 2025
Nutritional, Genes and Human Disease Laboratory, Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka, Bangladesh. Electronic address:
Background: Understanding the mutational landscape is critical for elucidating the molecular mechanisms driving cancer progression. This study aimed to profile somatic mutations in bladder cancer patients (N=7) from Bangladesh to provide insights into the genetic alterations underlying this malignancy.
Methods: We performed targeted sequencing of 50 oncogenes and tumor suppressor genes using the Ion AmpliSeq Cancer Hotspot Panel v2 on tumor and matched blood samples from seven bladder cancer patients.
Bioorg Med Chem Lett
September 2025
Department of Chemical Engineering, Analysis and Test Center, Shenyang University of Chemical Technology, Shenyang 110142, China. Electronic address:
Asiatic acid (AA) was used as the lead compound and 22 inhibitors of specificity protein 1 (Sp1) were designed and synthesized with modification at A ring and C-28 position of AA, whose structures were confirmed by HRMS, H NMR and C NMR. The growth inhibitory effects of Asiatic acid derivatives on human breast cancer cells (MCF-7) and cervical cancer cells (Hela) were determined by tetramethyl azole salt (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, MTT) colorimetric assay. The results showed that all of these compounds inhibited the proliferation of HeLa and MCF-7 cells, and all the derivatives showed stronger tumor cytotoxicity than AA, among which compounds I, II, and III were comparable to the positive control drug cisplatin.
View Article and Find Full Text PDFPhys Med Biol
September 2025
Institute of Applied Medical Engineering, Helmholtz Institute, RWTH Aachen University Medical Faculty, Pauwelsstraße 20, Aachen, 52074, GERMANY.
Objective: Magnetic particle imaging (MPI) opens huge possibilities in image-guided therapy. Its effectiveness is strongly influenced by the quality of the magnetic nanoparticles (MNP) used as tracers. Besides MNP optimization following different synthesis routes, MNP assembly into linear structures can significantly enhance their performance in MPI.
View Article and Find Full Text PDFEur J Med Chem
September 2025
NEUROFARBA Department, Sezione di Scienze Farmaceutiche, University of Florence, Via Ugo Schiff 6, Sesto Fiorentino, Florence, 50019, Italy. Electronic address:
In this study, we explored a dual-target strategy combining the inhibition of human carbonic anhydrase IX (hCA IX), a tumor-associated isoform, and glutathione peroxidase 4 (GPX4), a key regulator of ferroptosis. We demonstrated that the simultaneous inhibition of hCA IX and GPX4 disrupts redox and iron homeostasis, thereby enhancing cell death via ferroptosis. Three series of compounds were rationally designed and synthesized based on the ML162 scaffold using an integrated structural approach and their enzymatic inhibition was evaluated in vitro.
View Article and Find Full Text PDFBioorg Chem
September 2025
Entomology Department, Faculty of Science, Ain Shams University, Abbassia, 11566, Cairo, Egypt.
A strategically engineered, eco-conscious synthetic platform was developed to access a novel library of eighteen polyfunctionalized pyridine-based heterocycles through high-efficiency multicomponent and annulation strategies, using 2-amino-4-(4-chlorophenyl)-6-(p-tolyl)nicotinonitrile (M) as a privileged core. Structural diversity was maximized by integrating potent pharmacophores, including pyrido[2,3-d]pyrimidines, naphthyridines, triazines, and fused pyrrolo/tetrazolo motifs, via both conventional and accelerated (microwave/ultrasound-assisted) routes, affording excellent yields with high structural fidelity as confirmed by IR, H/C NMR, and mass spectrometry. Biological evaluation revealed that all synthesized compounds had excellent larvicidal efficacy against Culex pipiens larvae, especially 15 and 9, emerging as lead candidates that exhibited exceptional LC₅₀ values of 0.
View Article and Find Full Text PDF