Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Canine prostate cancer (cPCa) is an untreatable malignant neoplasm resulting in local tissue invasion and distant metastasis. MicroRNAs (miRs) are small non-coding RNAs that function as oncogenes or tumor suppressors. The purpose of this study was to characterize the expression of miRs that are altered in cPCa tissue. The expression levels of 277 mature miRs in prostatic tissue (n=5, respectively) were compared between the non-tumor and tumor groups using real-time PCR. Five miRs (miR-18a, 95, 221, 222 and 330) were up-regulated, but 14 miRs (miR-127, 148a, 205, 299, 329b, 335, 376a, 376c, 379, 380, 381, 411, 487b and 495) were down-regulated specifically in cPCa (P<0.05). These miRs have potential use as early diagnosis markers for cPCa and in miR-based therapy.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402193 | PMC |
| http://dx.doi.org/10.1292/jvms.16-0279 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Algorithm to detect ISUP ≥ 2 prostate cancer using canine detection.
World J Urol
September 2025
Bichat Claude Bernard Hospital, Public Assistance of Paris Hospitals, Paris, France.
Purpose: Screening and diagnosing ISUP ≥ 2 prostate cancer is challenging. This study aimed to determine whether canine detection could be beneficial addition to the ISUP ≥ 2 prostate cancer diagnostic protocol by creating a decision-making algorithm for men with suspected prostate cancer.
Methods: We conducted a prospective study at two urology institutions and a French veterinary school, including men with a suspicion of prostate cancer from November to April 2023, which were divided into two groups according to their prostate biopsy results.
Objective: To determine optimal CT perfusion (CTP) imaging parameters for evaluating the canine prostate and to assess the diagnostic utility of CTP combined with cytopathologic evaluation and B-Raf proto-oncogene (BRAF) gene mutation testing in dogs with prostate adenocarcinoma.
Methods: For this study, 10 male dogs were enrolled, comprising 4 healthy Beagles and 6 client-owned dogs with suspected prostatic neoplasia. Computed tomography perfusion was performed in the healthy dogs using varied contrast agent doses and injection durations.
Oral Supplementation of Thwaites Improves Sperm Cryotolerance Without Markedly Affecting Hematological, Biochemical, Seminal, or Testicular Profiles in Dogs.
Animals (Basel)
August 2025
Department of Obstetrics, Gynaecology and Reproduction, Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330, Thailand.
Thwaites (LST) has emerged as a potential supplement for enhancing male reproductive performance. This study evaluated the effects of long-term oral supplementation with LST on hematological parameters, semen characteristics, ultrasonographic measurements of the prostate gland and testes, and the cryopreservation potential of canine sperm. Six healthy male dogs received oral LST supplementation at a dosage of 10 mg/kg body weight once daily for 7 days (short-term).
View Article and Find Full Text PDFIncN-R plasmid co-integration contributing to extensive drug resistance in isolated from a canine prostatic abscess.
Microbiol Spectr
September 2025
Department of Veterinary Microbiology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand.
The emergence of multidrug-resistant (MDR) plasmids poses a significant global public health threat. This study characterized a novel multi-replicon IncN-R MDR plasmid pCUVET19-1426.1, harboring and 12 additional antimicrobial resistance genes (ARGs) in a newly identified sequence type 13037, isolated from a canine prostatic abscess.
View Article and Find Full Text PDFDevelopment of a Model for Predicting Enlarged Prostate Size in Noncastrated Dogs Through B-Mode Ultrasound.
Vet Med Int
July 2025
Departamento de Clínicas y Hospital Veterinario, Facultad de Veterinaria, Universidad de la República, Montevideo, Uruguay.
The prostate in noncastrated male dogs typically experiences an increase in weight and size as they age, which can result in the development of prostatic disorders. Benign prostatic hyperplasia (BPH) is the most common prostate disorder in these dogs. The purpose of this study was to develop a model that could differentiate between dogs with normal prostate sizes and those with enlarged prostate sizes.
View Article and Find Full Text PDF