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New syntheses of (±)-tashiromine and (±)-epitashiromine via enaminone intermediates. | LitMetric

New syntheses of (±)-tashiromine and (±)-epitashiromine via enaminone intermediates.

Beilstein J Org Chem

Molecular Sciences Institute, School of Chemistry, University of the Witwatersrand, Wits 2050, Johannesburg, South Africa.

Published: December 2016


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Article Abstract

The syntheses of the naturally occurring indolizidine alkaloid (±)-tashiromine and its unnatural epimer (±)-epitashiromine are demonstrated through the use of enaminone chemistry. The impact of various electron-withdrawing substituents at the C-8 position of the indolizidine core on the preparation of the bicyclic system is described.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238587PMC
http://dx.doi.org/10.3762/bjoc.12.256DOI Listing

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