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http://dx.doi.org/10.1016/j.ymthe.2016.12.003 | DOI Listing |
Appl Health Econ Health Policy
August 2025
Department of Epidemiology and Health Economics, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
Objective: The aim of this review is to identify and assess modelling approaches in published model-based economic evaluations of treatments for individuals with inherited bleeding disorders.
Methods: A literature search was performed on seven electronic databases, from database inception until 30 May, 2024. Inclusion criteria were cost-effectiveness or cost-utility analyses using decision-analytic models.
Vaccines (Basel)
August 2025
Ziphius NV, Zwijnaarde, 9052 Ghent, Belgium.
Messenger RNA (mRNA) vaccine technology has revolutionized the field of immunization, offering a non-infectious, non-genome-integrating platform that addresses many limitations of traditional vaccine modalities. Recent advancements in chemical modifications, delivery systems, and manufacturing processes have enhanced the stability, efficacy, and safety of RNA-based therapeutics, expanding their application beyond infectious diseases to include genetic disorders, cancer, and rare diseases. Central to the success of RNA vaccines is their ability to orchestrate a finely tuned immune response, leveraging both innate and adaptive immunity to achieve robust and durable protection.
View Article and Find Full Text PDFMicrosc Res Tech
August 2025
Institut für Biophysik, Universität für Bodenkultur Wien (BOKU), Vienna, Austria.
This study investigates the impact of environmental factors and lipid composition on the structural and morphological properties of DPPC/DOPC (1,2-Dipalmitoyl-sn-glycero-3-phosphocholine/1,2-dioleoyl-sn-glycero-3-phosphocholine) monolayers. Temperature plays a significant role in DPPC monolayer behavior; at 15°C and 20°C, DPPC exhibits liquid expanded-liquid condensed coexistence, while at 25°C, this coexistence region disappears. Divalent ions (CaCl) enhance more compact and uniform DPPC packing compared to monovalent ions (KCl), reducing mean area per molecule.
View Article and Find Full Text PDFCytokine Growth Factor Rev
June 2025
Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati (IITG), Guwahati, Assam 781039, India. Electronic address:
Oral cancer remains one of the deadliest diseases due to its aggressive nature, high metastatic potential, and limited therapeutic success. The tumor microenvironment (TME) serves as a central regulator in the metastasis of oral cancer by shaping tumor-stroma interactions, immune modulation, and metastatic dissemination. Among the key regulators of the TME, cytokines act as one of the molecular orchestrators, mediating inflammation, immune suppression, epithelial-mesenchymal transition (EMT), angiogenesis, and metastatic niche formation.
View Article and Find Full Text PDFCurr Opin Cell Biol
August 2025
Professor of Cell and Developmental Biology, Research Professor in the Life Sciences, Life Sciences Institute, University of Michigan, 210 Washtenaw Ave., Rm. 6437, Ann Arbor, MI 48109-2216, USA. Electronic address: