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Objective: To review the efficacy of functional electrical stimulation (FES) used for foot drop in people with multiple sclerosis (pwMS) on gait speed in short and long walking performance tests.
Data Sources: Five databases (Cochrane Library, CINAHL, Embase, MEDLINE, and PubMed) and reference lists were searched.
Study Selection: Studies of both observational and experimental design where gait speed data in pwMS could be extracted were included.
Data Extraction: Data were independently extracted and recorded. Methodologic quality was assessed using the Effective Public Health Practice Project tool.
Data Synthesis: Nineteen studies (described in 20 articles) recruiting 490 pwMS were identified and rated as moderate or weak, with none gaining a strong rating. All studies rated weak for blinding. Initial and ongoing orthotic and therapeutic effects were assessed regarding the effect of FES on gait speed in short and long walking tests. Meta-analyses of the short walk tests revealed a significant initial orthotic effect (t=2.14, P=.016), with a mean increase in gait speed of .05m/s, and ongoing orthotic effect (t=2.81, P=.003), with a mean increase of .08m/s. There were no initial or ongoing effects on gait speed in long walk tests and no therapeutic effect on gait speed in either short or long walk tests.
Conclusions: FES used for foot drop has a positive initial and ongoing effect on gait speed in short walking tests. Further fully powered randomized controlled trials comparing FES with alternative treatments are required.
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http://dx.doi.org/10.1016/j.apmr.2016.12.007 | DOI Listing |
Physiother Theory Pract
September 2025
School of Physical Therapy and Graduate Institute of Rehabilitation Science, College of Medicine, Chang Gung University, Taoyuan, Taiwan, ROC.
Background: Knee osteoarthritis (OA) causes pain and diminishes quality of life. Backward walking exercise (BWE) has been shown to improve lower muscle strength and reduce knee adduction moment, making it a recommended intervention for knee OA rehabilitation. This study aims to evaluate the effectiveness of BWE combined with conventional rehabilitation programs on pain intensity and disability among individuals with knee OA.
View Article and Find Full Text PDFJ Biomech
August 2025
Lampe Joint Department of Biomedical Engineering, UNC Chapel Hill & NC State University, Chapel Hill, NC, USA. Electronic address:
Walking is essential for maintaining independence and quality of life, yet aging may impair the neuromuscular function required for stable gait over time. This study sought to quantify age-related differences in step-to-step control during prolonged walking using detrended fluctuation analysis (DFA). We hypothesized that step-to-step changes in step length and step width would exhibit reduced temporal persistence over time, with more pronounced effects in older than in younger adults.
View Article and Find Full Text PDFBMJ Neurol Open
September 2025
Wolfson Institute of Population Health, Queen Mary University of London, Centre for Preventive Neurology, London, England, UK.
Background: Nitrous oxide (N₂O)-related neurotoxicity is a significant public health concern among young people in the UK. Recognition necessitates timely diagnosis, abstinence from N₂O consumption and replacement of vitamin B12, usually via intramuscular (IM) hydroxocobalamin. This service development project evaluated a self-injection programme (SIP) compared with a nurse-led approach, within an established ambulatory care pathway, with the aim of improving treatment adherence and completion.
View Article and Find Full Text PDFJ Exerc Rehabil
August 2025
Faculty of Care and Rehabilitation, Seijoh University, Toukai, Japan.
Load asymmetry in the lower limbs of patients with hip fracture is associated with decreased gait ability, impaired balance, and increased risk of fall. The modified sit-to-stand (STS), which combines positioning the foot behind with chair seat elevation, facilitates loading on the affected limb. This study aimed to investigate lower limb load asymmetry during STS and walking in patients with hip fracture after modified STS training.
View Article and Find Full Text PDFMov Disord Clin Pract
September 2025
Department of Physical Medicine and Rehabilitation, College of Physicians and Surgeons, Columbia University Medical Center, New York, New York, USA.
Background: The Scale for the Assessment and Rating of Ataxia (SARA) is the most used outcome measure in clinical trials for cerebellar ataxias. The minimal clinically important difference (MCID), a parameter used to assess meaningful change, is not clearly defined.
Objective: To help define MCID for SARA.