An α-helical peptidomimetic scaffold for dynamic combinatorial library formation.

Chem Commun (Camb)

Department of Chemistry, New York University, 100 Washington Square East, New York, NY 10003, USA. and Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK.

Published: December 2016


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Article Abstract

A novel oligobenzamide-based α-helix mimetic was designed and synthesised with either imine or hydrazone functionalities that serve both to pre-organise the side-chain vectors to mimic the i, i + 4 and i + 7 residues of an α-helix, and to allow for the facile creation of dynamic libraries.

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http://dx.doi.org/10.1039/c6cc07787kDOI Listing

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