Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Objective: To assess the value of urinary liver-type fatty acid-binding protein (L-FABP) in early assessment of the severity of traumatic brain injury and in predicting the occurrence of acute kidney injury (AKI) following the brain injury.
Methods: Sixty-five patients with traumatic brain injury patients were divided into 4 groups according to their Glasgow coma scale (GCS) scores. Blood and urine samples were collected at 2, 6, 12, 24, 48 and 72 h after the injury to detect serum creatinine (SCr) level using biochemical analyzer and urinary L-FABP using enzyme-linked immunosorbent assay (ELISA), with samples from 15 healthy adults as controls. The correlations were analyzed among SCr, urinary L-FABP, GCS score upon admission and AKI occurrence.
Results: The patients with moderate to severe brain injuries showed significantly higher SCr and urinary L-FABP levels than the control group (P<0.05). GCS score of the patients was inversely correlated with the levels of SCr and urinary L-FABP (P<0.05), and the changes were more prominent in urinary L-FABP than in SCr. The incidence of AKI was 21.54% in these patients. In patients with AKI, urinary L-FABP reached the peak level as soon as 6 h after the injury, as compared with 24 to 48 h when peak SCr level occurred.
Conclusion: Urinary L-FABP can be used as a marker for early assessment of the severity of traumatic brain injury and for predicting the occurrence of AKI following the injury.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Nonsteroidal anti-inflammatory drugs (NSAIDs) are extensively utilized for their analgesic and anti-inflammatory efficacy, yet they pose a significant risk for renal adverse events, notably drug-induced acute interstitial nephritis (DI-AIN). Prompt recognition and appropriate management are paramount to prevent irreversible kidney damage. We present the case of a 46-year-old male with NSAID-induced DI-AIN, emphasizing the diagnostic utility of a specific urinary biomarker profile and the rationale for empirical steroid therapy initiated before histopathological confirmation.
View Article and Find Full Text PDFTestosterone contributes sex differences of urinary biomarkers for nephrotoxicity in rats.
J Toxicol Sci
August 2025
Drug Safety and Pharmacokinetics, Taisho Pharmaceutical Co., Ltd.
Urinary biomarkers have been used widely in non-clinical toxicity studies to detect kidney dysfunction/injury caused by drugs under development. Although their usefulness to evaluate nephrotoxicity has been well studied, knowledge about sex differences in the urinary excretion levels of these biomarkers remains inadequate. We previously demonstrated the existence of sex differences in the excretion levels of urinary biomarkers and that these differences were associated with the endogenous testosterone levels.
View Article and Find Full Text PDFCombination of Urinary Biomarkers for Early Detection of Patients With Acute Kidney Injury After Transcatheter Aortic Valve Implantation.
J Cardiothorac Vasc Anesth
June 2025
Department of Anesthesiology, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan. Electronic address:
Objectives: To investigate whether urinary biomarker paneling improves the accuracy of diagnosis of acute kidney injury (AKI) after transcatheter aortic valve implantation (TAVI).
Design: Post-hoc analysis of a prospective, single-center study.
Setting: University hospital.
Biomarkers and early-onset acute kidney injury in critically ill COVID-19 patients, a prospective monocentric observational study.
BMC Nephrol
July 2025
CHU Clermont-Ferrand, Service de Réanimation Médicale, Clermont- Ferrand, France.
Background: The present study evaluated the diagnostic and prognostic value of biomarkers, including soluble forms of the receptor for advanced glycation end-products (s-RAGE), soluble urokinase plasminogen activator receptor (SuPAR), and others, for the occurrence of early-onset acute kidney injury (EO-AKI), EO-AKI non-recovery, day-90 major adverse kidney events (MAKE-90), and day-90 mortality in critically ill patients with Coronavirus Disease-19 (Covid-19).
Methods: A single-center, prospective study was conducted at the University Hospital of Clermont-Ferrand, France, between March 2020 and February 2021. The study included adult patients suffering from severe pneumonia caused by the SARS-CoV-2 virus, who were admitted to the hospital's intensive care unit.
Urinary [TIMP-2]•[IGFBP7], TIMP-2, IGFBP7, NGAL, and L-FABP for the prediction of acute kidney injury following cardiovascular surgery in Japanese patients.
Clin Exp Nephrol
April 2025
Department of Anesthesiology and Intensive Care Medicine, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nankoku, Kochi, 783-8505, Japan.
Background: Acute kidney injury (AKI) following cardiac surgery is common and is associated with poor outcomes. The combination of urinary tissue inhibitor of metalloproteinase 2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7) is a strong predictor of AKI after cardiac surgery. However, most studies have focused on non-Asian populations, and comparisons with other AKI biomarkers or the optimal timing for measurement have yet to be explored.
View Article and Find Full Text PDF