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We report the case of a 66-year-old man with seropositive rheumatoid arthritis who developed neurologically asymptomatic rheumatoid meningitis (RM) revealed by MRI. RM worsened and chest CT showed pericardial effusion, pleural effusion, and bilateral consolidation, and his serum C3 level was decreased. We diagnosed systemic rheumatic vasculitis based on these findings. After a review of more than 20 previously reported cases of RM, this is the first case of RM without central nerve system symptoms.
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http://dx.doi.org/10.1080/14397595.2016.1232333 | DOI Listing |
Cureus
July 2025
Internal Medicine, Medical Associates of North Texas, Fort Worth, USA.
Paget's disease of bone is a chronic skeletal disorder characterized by disorganized bone remodeling. Although often asymptomatic, it is frequently first detected through elevated alkaline phosphatase (ALP). Given ALP's nonspecific nature, its elevation requires a comprehensive evaluation for hepatic, biliary, and bone pathology.
View Article and Find Full Text PDFZ Rheumatol
August 2025
Research Department, Reha Rheinfelden, Salinenstr. 98, 4310, Rheinfelden, Schweiz.
A 46-year-old female patient had been suffering from multiple symptoms such as arthralgia, myalgia, general fatigue, exhaustion, concentration problems, forgetfulness, difficulty falling asleep and sleeping through the night and depression since the age of 27 years old. Rheumatological preliminary findings revealed rheumatoid arthritis with a lack of response to basic treatment as well as secondary fibromyalgia. Supplementary metabolic examinations were carried out in the case of laboratory tests for hypouricemia, which showed massively increased xanthine levels in the urine.
View Article and Find Full Text PDFJ Orthop Case Rep
August 2025
Department of Orthopaedics, Yashoda Hospital and Research Centre, Ghaziabad, Uttar Pradesh, India.
Introduction: Prosthetic joint infections (PJIs) are a serious complication of arthroplasty, often necessitating prolonged therapy and revision surgeries. Haemophilus influenzae is an uncommon cause of PJI, especially in immunocompromised individuals and individuals with co-morbidities. Its fastidious nature frequently leads to negative cultures, delaying diagnosis and targeted therapy.
View Article and Find Full Text PDFTrials
August 2025
Translational & Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, UK.
Background: Dendritic cells are professional antigen presenting cells with the ability, in their immature state, to induce tolerance in T cells. A protocol to develop phenotypically stable tolerogenic dendritic cells (TolDC) was developed in Newcastle and cells administered to participants in the phase I AuToDeCRA study, demonstrating that TolDC were safe and well tolerated. More knowledge of the TolDC product is now needed, such as optimal dose, route of administration and antigen loading.
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