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Article Abstract
Streptococcus gallolyticus is a commensal bacterium responsible for infectious endocarditis in the elderly, which has frequently been associated with colonic carcinoma. Whether this species is a cause or a consequence of colorectal cancer remains unknown. We recently demonstrated that S. gallolyticus Pil3 pilus is required for adhesion to colonic mucus and for colonization of mouse distal colon. We show here that Pil3 pilus binds equally well to human colonic mucins derived from HT29-MTX cells and to human stomach mucins from healthy donors. In addition, we have found that Pil3 also binds to human fibrinogen, which expands the repertoire of Pil3 host ligands.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5153612 | PMC |
| http://dx.doi.org/10.1080/19490976.2016.1239677 | DOI Listing |
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Article Synopsis
- Streptococcus gallolyticus, linked to increased bacteremia and infective endocarditis in the elderly, is also associated with colorectal cancer, prompting research on its interaction with human colonic cells.* -
- The study demonstrated that S. gallolyticus strain UCN34 adheres more strongly to mucus-producing colonic cells, with this attachment relying on the Pil3 pilus operon, which varies in expression among the bacteria.* -
- Researchers created a mutant lacking the pil3 gene, finding it couldn't colonize the mouse colon, establishing a new murine model for studying intestinal colonization by S. gallolyticus.*