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Purpose Of The Study: To study the role of endometrial and subendometrial blood flow measured by 3D power Doppler as predictors of pregnancy in frozen embryo transfer (FET) cycles.
Methods: A hospital-based prospective study of two hundred and twenty-one (221) women undergoing FET cycles with a triple-line endometrium ≥7 mm on day 14 endometrial and subendometrial blood flow was assessed using 3D power Doppler, and various indices endometrial volume, subendometrial volume and their vascularisation index (VI), flow index (FI) and vascularisation flow index (VFI) were obtained and compared between the pregnant and the non-pregnant group. Primary outcome was clinical pregnancy.
Results: Out of 221 women, 97(43.89 %) became pregnant, while 124 (56.10 %) failed to become pregnant. The endometrial volume was comparable between the two groups. Endometrial VI, FI and VFI were significantly higher in the pregnant as compared to the non-pregnant group. There was a significant difference in subendometrial VI and VFI between the two groups, but FI was similar.
Conclusions: Endometrial and subendometrial vascularity by 3D power Doppler can be a useful parameter in predicting pregnancy in FET cycles.
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http://dx.doi.org/10.1007/s13224-016-0871-5 | DOI Listing |
J Clin Med
August 2025
ART Center of the Department of Obstetrics and Gynecology, CHU of Liège-Citadelle Site, University of Liège, 4000 Liege, Belgium.
: The management of patients with recurrent implantation failure (RIF) or recurrent pregnancy loss (RPL) is a real challenge. Studying endometrial proliferation and vascularization by ultrasound during the embryo implantation window is an option for investigating these failures. This approach involves measuring the endometrial volume, the uterine arteries pulsatility index (PI), and the sub-endometrial flow index (VFI).
View Article and Find Full Text PDFActa Biomater
August 2025
Center for Reproductive Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, 322000, China; Department of Assisted Reproduction Women's Hospital School of Medicine Zhejiang University Ha
Intrauterine perfusion of platelet-rich plasma (PRP) is often used for the treatment of intrauterine adhesions (IUA). However, the further application of PRP is limited by its difficulty in attaching to the endometrial surface and its inability to release growth factors persistently. Therefore, in this study, a dual-network (DN) hydrogel was prepared by using hyaluronate gel as the matrix and cross-linked PRP, which was applied to the clinical treatment of IUA.
View Article and Find Full Text PDFQuant Imaging Med Surg
May 2025
Clinical Research Center for Reproduction and Genetics in Hunan Province, Reproductive & Genetic Hospital of CITIC-Xiangya, Changsha, China.
Background: High rates of infertility and pregnancy complications in patients with intrauterine adhesion (IUA) even after surgical repair may be associated with poor endometrial receptivity (ER). In our previous study, we found that changes occurred in ER from the day of ovulation to the day of transfer in patients with a normal uterine cavity during natural cycles. However, the changes in ER ultrasound indicators in patients with a history of IUA during natural cycles are unclear, and this study thus aimed to analyze these changes.
View Article and Find Full Text PDFJ Int Med Res
April 2025
Henan Key Laboratory of Fertility Protection and Aristogenesis; Department of Reproductive Center, Luohe Central Hospital, China.
Successful embryo implantation relies on embryo quality, endometrial receptivity, and the synchronized development of both. In recent years, methods for assessing endometrial receptivity have considerably advanced, shifting from traditional imaging techniques to modern molecular biology approaches. The evaluation of endometrial thickness, morphology, subendometrial blood flow, and peristalsis before implantation has become less prominent, whereas molecular markers such as pinopodes, integrin αvβ3, its ligand osteopontin, and homologous box gene A10 are widely used in clinical practice for assessing endometrial receptivity.
View Article and Find Full Text PDFBMC Pregnancy Childbirth
March 2025
Department of Obstetrics and Gynecology, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey.
Background: The purpose of this study was to investigate the effects of subendometrial PRP injection on endometrial thickness and pregnancy outcomes in patients with a history of unresponsive thin endometrium undergoing frozen-thawed embryo transfer (FET).
Methods: This prospective cohort study was conducted at Acibadem Mehmet Ali Aydinlar University-Istanbul, Turkey. Women with a history of suboptimal endometrial proliferation (< 7 mm) were offered to participate in the study.