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Article Abstract
Several derivatives of aminobenzoboroxole have been prepared starting from 2-boronobenzaldehyde. All of these derivatives have been evaluated for their -mycobacterial activity on and cytotoxicity on breast cancer cell line MCF7. Based on these studies, all the tested molecules have been found to be generally non-toxic and benzoboroxoles with unsubstituted (primary) amines have been found to exhibit good -mycobacterial activity. Some of the key compounds have been evaluated for their -tubercular activity on H37Rv using 7H9 and GAST media. 7-Bromo-6-aminobenzoboroxole has been identified as the lead candidate compound for further development.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021310 | PMC |
| http://dx.doi.org/10.1016/j.tet.2016.03.038 | DOI Listing |
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