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http://dx.doi.org/10.1016/S0140-6736(16)31150-3 | DOI Listing |
Chaos
September 2025
Instituto de Física, Universidade Federal de Alagoas, Maceió, Alagoas 57072-970, Brazil.
Neuronal heterogeneity, characterized by a multitude of spiking neuronal patterns, is a widespread phenomenon throughout the nervous system. In particular, the brain exhibits strong variability among inhibitory neurons. Despite the huge neuronal heterogeneity across brain regions, which in principle could decrease synchronization due to differences in intrinsic neuronal properties, cortical areas coherently oscillate during various cognitive tasks.
View Article and Find Full Text PDFRadiol Artif Intell
September 2025
Department of Radiology, Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital, No. 197 Ruijin Er Road, Shanghai 200025, China.
Purpose To assess the effectiveness of an explainable deep learning (DL) model, developed using multiparametric MRI (mpMRI) features, in improving diagnostic accuracy and efficiency of radiologists for classification of focal liver lesions (FLLs). Materials and Methods FLLs ≥ 1 cm in diameter at mpMRI were included in the study. nn-Unet and Liver Imaging Feature Transformer (LIFT) models were developed using retrospective data from one hospital (January 2018-August 2023).
View Article and Find Full Text PDFBiomed Environ Sci
August 2025
Precision Key Laboratory of Public Health, School of Public Health, Guangdong Medical University, Dongguan 523808, Guangdong, China;Maternal and Child Research Institute, Shunde Women and Children's Hospital, Guangdong Medical University, Foshan 528300, Guangdong, China.
Objective: Humans are exposed to complex mixtures of environmental chemicals and other factors that can affect their health. Analysis of these mixture exposures presents several key challenges for environmental epidemiology and risk assessment, including high dimensionality, correlated exposure, and subtle individual effects.
Methods: We proposed a novel statistical approach, the generalized functional linear model (GFLM), to analyze the health effects of exposure mixtures.
Elife
September 2025
Department of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, United States.
The microglial surface protein Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) plays a critical role in mediating brain homeostasis and inflammatory responses in Alzheimer's disease (AD). The soluble form of TREM2 (sTREM2) exhibits neuroprotective effects in AD, though the underlying mechanisms remain elusive. Moreover, differences in ligand binding between TREM2 and sTREM2, which have major implications for their roles in AD pathology, remain unexplained.
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