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http://dx.doi.org/10.21037/jtd.2016.05.19 | DOI Listing |
JBJS Rev
September 2025
Joondalup Health Campus, Joondalup, Australia.
Background: Postoperative swelling is a common complication after total knee arthroplasty (TKA), associated with pain, limited mobility, and delayed recovery. This study aimed to systematically review the literature on interventions that reduce postoperative swelling, categorized into preoperative, intraoperative, and postoperative phases.
Methods: A Preferred Reporting Items for Systematic Reviews and Meta-Analyses-compliant search of PubMed, Medline, Embase, and Cochrane databases was performed for clinical studies evaluating interventions to reduce swelling after primary TKA.
Am J Med
August 2025
Department of Epidemiology, College of Public Health, University of South Florida, Tampa, Florida, USA. Electronic address:
Background: The effect of chronic aspirin use on the development of heart failure remains uncertain, and no prior observational study has evaluated it as a time-dependent exposure.
Methods: We analyzed data from four prospective cohort studies involving 26,941 individuals free of cardiovascular disease but at risk for heart failure. The baseline mean age was 60.
N Engl J Med
August 2025
Cardiology Department, Nimes University Hospital, Montpellier University, ACTION Study Group, Nimes, France.
Background: An appropriate duration of dual antiplatelet therapy after percutaneous coronary intervention for acute myocardial infarction that has been treated with guideline-recommended complete revascularization and a contemporary drug-eluting stent remains unclear.
Methods: We conducted a multicenter, open-label, randomized trial at 40 European sites. Adults with acute myocardial infarction who had undergone successful complete revascularization within 7 days after the infarction and had subsequently completed 1 month of dual antiplatelet therapy with no ischemic or major bleeding events were randomly assigned to transition to a P2Y12 inhibitor as monotherapy or to continue dual antiplatelet therapy for an additional 11 months.
N Engl J Med
August 2025
ACTION Group, Paris.
Background: The appropriate antithrombotic regimen for patients with chronic coronary syndrome who are at high atherothrombotic risk and receiving long-term oral anticoagulation remains unknown.
Methods: We conducted a multicenter, double-blind, randomized, placebo-controlled trial in France involving patients with chronic coronary syndrome who had undergone a previous stent implantation (>6 months before enrollment) and were at high atherothrombotic risk and currently receiving long-term oral anticoagulation. The patients were randomly assigned in a 1:1 ratio to receive aspirin (100 mg once daily) or placebo; all the patients continued to receive their current oral anticoagulation therapy.
J Neurol
August 2025
Department of Clinical and Experimental Sciences, Neurology Unit, University of Brescia, Brescia, Italy.
Background: Antiplatelet treatment is associated with hematoma expansion (HE) and poor outcome in intracerebral hemorrhage (ICH). We aimed to describe the characteristics of ICH associated with dual antiplatelet treatment (DAPT), compared with single (SAPT) and no antiplatelet treatment (NAPT).
Methods: A retrospective analysis of ICH patients admitted at nine academic stroke centers in Italy, Germany, and China was conducted.