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Introduction Episodes of apnoea are common in extremely preterm infants and usually treated with caffeine and respiratory support. Understanding differences in apnoea definitions, monitoring practices, and use of respiratory stimulants is essential to improve future treatment. Methods Between March and July 2024, one lead consultant at European tertiary neonatal intensive care units (NICUs) was invited to complete to a web-based survey on respiratory practices in extremely preterm infants.
View Article and Find Full Text PDFBeyond Mean Absolute Relative Difference (MARD): Rethinking Continuous Glucose Monitoring (CGM) Evaluation for Real-World Diabetes Care.
Cureus
September 2025
Department of Internal Medicine, Civil Hospital of Ovada, Ovada, ITA.
Continuous glucose monitoring (CGM) has transformed diabetes mellitus management, evolving from a supportive monitoring tool to a central pillar of care. For people with type 1 diabetes and many insulin-treated individuals with type 2 diabetes, CGM now directly informs treatment decisions, especially when integrated with automated insulin delivery (AID) systems. In these hybrid closed-loop systems, sensor data drives real-time insulin adjustments, meaning that accuracy is not just a matter of measurement quality; it is a matter of patient safety.
View Article and Find Full Text PDFIV loop diuretics remain the cornerstone of treatment for acute decompensated heart failure (ADHF). Although previous meta-analyses have compared continuous infusion and intermittent bolus dosing of IV loop diuretics, their respective renal effects remain unclear. Given the prognostic significance of worsening renal function (WRF) or acute kidney injury in ADHF, evaluating the renal safety of different diuretic regimens is essential.
View Article and Find Full Text PDFpneumonia in thoracic organ transplantation: Current perspectives and updates.
JHLT Open
November 2025
Professor of Medicine, Transplant Infectious Diseases and Transplant Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
pneumonia (PCP) is an opportunistic infectious disease in thoracic solid organ transplant (SOT) recipients, occurring particularly in the setting of augmented immunosuppression. Thoracic allograft recipients are particularly at risk of severe outcomes. Diagnosis is frequently delayed due to nonspecific clinical findings and challenges in ruling out other opportunistic pathogens and distinguishing between pneumonia and colonization.
View Article and Find Full Text PDFMedical Therapy in Patients with Heart Failure: A Delphi Consensus from Italian Cardiologists.
J Clin Med
August 2025
Department of Cardiology, Ospedale Regina Montis Regalis, Strada del Rocchetto 99, 12084 Mondovì, Italy.
: Adherence to current clinical guidelines is crucial for ensuring optimal therapy in patients with heart failure (HF). This study aims to explore how cardiologists, as specialists in heart failure, approach the clinical scenarios encountered in the management of HF patients, in line with the recommended guidelines. A heart failure-focused meeting was organized, during which participating cardiologists engaged actively.
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