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http://dx.doi.org/10.1016/j.arbres.2016.05.023 | DOI Listing |
Front Oncol
August 2025
Division of Hematology, Department of Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Extramedullary relapse of acute lymphoblastic leukemia (ALL) is usually associated with poor prognosis. Chimeric antigen receptor T cell (CAR-T cell) therapy followed by allogeneic hematopoietic stem cell transplantation is beneficial for relapsed/refractory (r/r) B cell acute lymphoblastic leukemia (B-ALL). Here, we report a B-ALL patient with extramedullary relapse involving several organs, including multiple lymph nodes and the breast, kidney, uterus and pancreas.
View Article and Find Full Text PDFBMJ Case Rep
September 2025
Obstetrics and Gynaecology, King George's Medical University, Lucknow, Uttar Pradesh, India.
The rare endocrine condition known as Van Wyk-Grumbach syndrome (VWGS) is typified by delayed bone age, multicystic ovaries, isosexual precocious puberty and increased, untreated primary hypothyroidism. It typically presents in paediatric patients but can occasionally be missed until adulthood. We report an unusual adult presentation of VWGS in a short-statured woman in her early 20s who presented with menorrhagia-induced severe anaemia, hypothyroid features and multicystic ovaries.
View Article and Find Full Text PDFBMJ Case Rep
September 2025
Department of Internal Medicine, Hospital General Universitario Gregorio Marañón, Madrid, Community of Madrid, Spain.
Uveitis is a significant cause of visual impairment and is often linked to underlying systemic immune-mediated conditions. Retroperitoneal fibrosis, characterised by the proliferation of fibrotic tissue in the retroperitoneum, can similarly be associated with autoimmune or autoinflammatory diseases. While both conditions have been reported in the context of systemic disorders, their co-occurrence in the absence of a defined systemic diagnosis is exceedingly rare, with only two such cases previously documented.
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September 2025
Manchester Royal Eye Hospital, Manchester, UK.
We report a case of a young woman who presented with a vitreous haemorrhage associated with a combined hamartoma of the retina and retinal pigment epithelium (CHRRPE). During her clinical course, while the vitreous haemorrhage resolved, the lesion enlarged with a worsening epiretinal membrane. The patient's visual acuity reduced from 0.
View Article and Find Full Text PDFAnn Med Surg (Lond)
September 2025
General Surgery, Wad Medani College of Medical Sciences & Technology, Wad Madani, Sudan.
Introduction And Importance: Meckel's diverticulum (MD) is the most common congenital anomaly of the gastrointestinal tract, typically asymptomatic but occasionally presenting with complications such as bleeding, obstruction, or rarely, perforation. Symptomatic MD is unusual in the elderly, often mimicking other acute abdominal conditions and posing diagnostic challenges, especially in low-resource settings.
Case Presentation: We report a case of a 64-year-old male presenting with a 2-day history of right iliac fossa pain, fever, nausea, and vomiting.