Inhibitory activity of avibactam against selected β-lactamases expressed in an isogenic Escherichia coli strain.

Diagn Microbiol Infect Dis

Department of Medical Biotechnologies, University of Siena, Siena, Italy; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy; Clinical Microbiology and Virology Unit, Florence Careggi University Hospital, Florence, Italy; Don Carlo Gnocchi Foundation, Florence,

Published: September 2016


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Article Abstract

Avibactam restored the in-vitro antibacterial activity of ceftazidime, ceftaroline, and aztreonam against isogenic Escherichia coli expressing class A, class C, and class D β-lactamases. The enzymes included TEM and CTX-M extended spectrum β-lactamases, ACT, CMY and FOX AmpC-type enzymes, and carbapenemases including rarer KPC variants and OXA-139.

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http://dx.doi.org/10.1016/j.diagmicrobio.2016.03.002DOI Listing

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