Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Hypodermin A (HA) is a serine esterase that degrades complement, a key element of the innate immune system. Immunosuppressive properties of HA have previously been studied in vitro. However, such properties have not been fully demonstrated in vivo. The aim of this study was to evaluate the effect of HA in inhibiting allograft rejection in an HA transgenic mouse model.
Methods: FVB (HA transgenic mice or wild-type mice) to BALB/c mice skin transplantation model were used. Skin grafts were analyzed by histology, immunohistochemistry, and Western blotting.
Results: HA overexpression resulted in significantly prolonged skin allograft survival. Histologic changes in the skin allografts paralleled the gross appearance of rejection. ELISA and Western blotting showed that HA significantly reduced the content of complement C3 and C9 in HA skin allografts. The expressions of CD4, B7-2, and MHC class II were all significantly suppressed in HA skin allografts compared with the control group.
Conclusions: These findings suggest that HA effectively prolongs skin allograft survival. The study results provide insight into a promising strategy to improve the survival of grafts in humans.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jss.2016.03.037 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Delayed autografting in the face and hands: The role of allografts in burn wound bed preparation.
JPRAS Open
September 2025
Department of Plastic, Reconstructive, & Aesthetic Surgery, Singapore General Hospital, Outram Road, Singapore 169608, Singapore.
Introduction: Burn injuries affecting specialised areas such as the face and hands require durable skin coverage and complete graft "take" to prevent scarring and functional impairment. Failure to achieve these outcomes can lead to long-term complications. This presentation aims to describe an approach of delayed autografting in these regions, following a "trial of allograft" to optimise wound bed preparation.
View Article and Find Full Text PDFAcoustofluidic system for targeted antibody removal in transplantation: Enabling small-volume therapeutic apheresis.
Sci Adv
September 2025
Duke Transplant Center, Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA.
Antibody-mediated rejection is a leading cause of allograft failure and mortality in pediatric solid organ transplant recipients. Current apheresis systems require large blood volumes and are primarily designed for adults, making them unsuitable for children and small animals. These systems often indiscriminately remove both harmful and protective antibodies, increasing the risk of complications such as life-threatening infections.
View Article and Find Full Text PDFRetrospective Evaluation of Human Amniotic Allografts for Diabetic Foot Ulcers and Venous Leg Ulcers Treated by an In-Home Mobile Wound Clinic.
J Am Podiatr Med Assoc
September 2025
*West Coast Wound & Skin Care, Burbank, CA.
Background: The objective is to evaluate the differences in the efficacy of wound care algorithms for diabetic foot ulcers (DFUs) and venous leg ulcers (VLUs) treated by a mobile wound clinic. Most patients requiring home treatment performed worse with the standard of care (SOC) compared to those in traditional outpatient clinics, especially chronic wounds associated with multiple comorbidities.
Methods: A retrospective chart review was conducted on one year's data from patient records of a mobile wound clinic (July 2022 - June 2023) involving patients suffering from DFU and VLU.
Cryopreserved Total Skin Allografts From Living Donors for Complex Wound Management: A New Paradigm in Regenerative Wound Care.
Int Wound J
September 2025
Department of Pathology, Dr. Ernesto Torres Galdames Hospital, Iquique, Chile.
Skin allografts are essential in managing complex wounds, yet their availability is limited by low post-mortem donation rates. Skin harvested during body contouring surgeries offers a novel and sustainable source to expand tissue supply. We conducted a retrospective descriptive study at the Tarapacá Skin and Tissue Bank from January 2022 to December 2024.
View Article and Find Full Text PDFImpact of hospital procedure volume on inpatient outcomes of burns covering 20-50 % of the total body surface receiving skin allograft: An analysis of the US Nationwide Inpatient Sample 2005-2020.
Burns
August 2025
Department of Plastic Surgery, Chung Shan Medical University Hospital, No. 110, Sec., Jianguo N. Rd., South Dist., Taichung City 402306, Taiwan. Electronic address:
Objective: This study examined how hospital procedure volume influences outcomes of burn patients receiving skin allografts.
Methods: Data of adults ≥ 18 years with burns of 20-50 % of the total body surface area who received skin allografts were extracted from the US Nationwide Inpatient Sample (NIS) database 2005-2020. Hospitals were categorized into low- and high-volume based on an annual number of skin allograft procedures, and patients were categorized by type of hospital at which they received treatment.