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A variety of traumatic and infectious processes can cause acute onset of hip pain and difficulty walking. Without a history of trauma, a common cause is transient (or "toxic") synovitis, but serious infectious causes, such as septic arthritis of the hip or osteomyelitis, must be ruled out. Differentiating between septic arthritis of the hip (a true emergency) and transient synovitis of the hip (a much more benign inflammatory process) can be difficult. The Kocher criteria have proven to be helpful in making the distinction between these two conditions, and they are reviewed in this article. In addition, imaging studies, especially hip ultrasound, are extremely helpful in the evaluation of the painful hip. [Pediatr Ann. 2016;45(6):e209-e213.].
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http://dx.doi.org/10.3928/00904481-20160427-01 | DOI Listing |
Int J Mol Sci
August 2025
Department of Biochemistry and Molecular Biology, School of Medicine, Chosun University, Gwangju 61452, Republic of Korea.
Osteoarthritis (OA) is the most prevalent form of joint arthritis, frequently associated with aging, mechanical wear, and inflammation. Our previous work demonstrated that cathelicidin-related antimicrobial peptide (Cramp) is upregulated in mouse OA cartilage, and that transient knockdown (KD) of Cramp in cultured chondrocytes decreases IL-1β-induced expression of matrix-degrading enzymes. The aim of this study was to determine the in vivo role of Cramp in OA pathogenesis using whole-body Cramp knockout (KO) mice.
View Article and Find Full Text PDFSkeletal Radiol
August 2025
Department of Pediatric Orthopedics and Sports Medicine, Riley Hospital for Children at IU Health, Indiana University School of Medicine, 575 Riley Hospital Dr., Indianapolis, IN, 46202, USA.
Objective: To determine whether decreased femoral head enhancement on MRI differentiates septic arthritis from transient synovitis.
Materials And Methods: This retrospective study included children < 10 years old with hip effusion on post-contrast MRI for suspected musculoskeletal infection. Two pediatric radiologists independently assessed femoral head enhancement.
BMC Med
July 2025
Department of Veterinary Clinical Sciences, Louisiana State University, Dr Skip Bertman, Baton Rouge, LA, USA.
Background: The use of micro-particulate allografts is rising, but knowledge about the protein characterization and biocompatibility of umbilical cord-derived allografts (UC) in vivo is limited.
Methods: Proteomic analyses using mass spectrometry (MS) determined equine UC protein relative quantification and functions using total spectral counts (TSC). UC cytokines were quantified by enzyme-linked immunosorbent assay (ELISA).
Cureus
June 2025
Pediatric Hospital Medicine, University of Utah School of Medicine, Salt Lake City, USA.
Vaccines in the pediatric population are crucial in preventing infectious diseases, but rare inflammatory responses can arise, particularly in patients with suspected immunodeficiency. This case highlights a unique inflammatory reaction mimicking septic arthritis following closely spaced pneumococcal vaccines (PPSV23) in a child undergoing immunodeficiency work-up. A previously healthy five-year-old Caucasian female with a history of recurrent bacterial infections presented with a two-day history of left knee swelling and pain after receiving two pneumococcal vaccines within a five-week interval due to a scheduling error.
View Article and Find Full Text PDFAnn Emerg Med
June 2025
Department of Pediatric Emergency Medicine, Connecticut Children's, Hartford, CT; Department of Pediatrics, University of Connecticut School of Medicine, Farmington, CT.
Study Objective: To determine the diagnostic accuracy of point-of-care ultrasound (POCUS) performed by pediatric emergency physicians for the diagnosis of hip effusion.
Methods: This multicenter, prospective study was conducted in 5 pediatric emergency departments (PEDs) in the United States and Australia from October 2019 to October 2023. Children aged 18 years and younger who presented to the PED with clinical presentation requiring radiology-performed ultrasound (RADUS) for evaluation of a hip effusion were eligible.