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Fertility preservation in the cancer setting, known as oncofertility, is a field that requires cross-disciplinary interaction between physicians, basic scientists, clinical researchers, ethicists, lawyers, educators, and religious leaders. Funded by the National Institutes of Health, the Oncofertility Consortium (OC) was formed to be a scientifically grounded, transparent, and altruistic resource, both intellectual and monetary, for building this new field of practice capable of addressing the unique needs of young patients with cancer. The OC has expanded its attention to include other nonmalignant conditions that can threaten fertility, and the work of the OC now extends around the globe, involving partners who together have created a community of shared effort, resources, and practices. The OC creates materials that are translated, disseminated, and amended by all participants in the field, and local programs of excellence have developed worldwide to accelerate the pace and improve the quality of oncofertility research and practice. Here we review the global oncofertility programs and the capacity building activities that strengthen these research and clinical programs, ultimately improving patient care.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894337 | PMC |
http://dx.doi.org/10.1200/JGO.2015.000307 | DOI Listing |
Clin Case Rep
September 2025
Department of Thoracic Surgery, Fu Xing Hospital, the Eighth Clinical Medical College Capital Medical University Beijing China.
Lactation-associated breast cancer poses diagnostic challenges due to physiological breast changes that may mask malignancies. Triple-negative breast cancer (TNBC) during lactation is rare and aggressive, requiring vigilant evaluation and treatment. This report highlights the diagnostic dilemma of recurrent cystic breast lesions during lactation, which can mimic benign conditions like galactoceles but may conceal aggressive TNBC, leading to potential delays in diagnosis despite initial conservative approaches such as aspiration.
View Article and Find Full Text PDFReports (MDPI)
August 2025
Center for Human Reproduction, International University of Health and Welfare Hospital, 537-3, Iguchi, Nasushiobara, Tochigi 329-2763, Japan.
Pituitary adenomas, also termed pituitary neuroendocrine tumors, pose a significant risk of hypogonadotropic hypogonadism (HH) after surgical resection, with profound consequences for fertility and sexual function in young patients. We present the case of a 29-year-old man from rural Japan who developed severe HH and azoospermia following two transsphenoidal resections for a large pituitary adenoma. Despite early engagement with neurosurgery teams, fertility management was delayed by the absence of on-site endocrinology expertise and limited local oncofertility resources.
View Article and Find Full Text PDFFertil Steril
August 2025
Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois. Electronic address:
Importance: This systematic review investigates outcomes for unassisted pregnancies in cancer survivors. Although prior studies have examined pregnancy outcomes for cancer survivors, clarifying the outcomes specifically for unassisted pregnancies can help guide patient and provider expectations and improve fertility preservation counseling.
Objective: The primary objective of this systematic review was to identify the impacts of cancer and its treatment on fertility, measured as the live birth rate among cancer survivors with an unassisted pregnancy.
Cancer Treat Res Commun
September 2025
Department of International Health, Care and Public Health Research Institute CAPHRI, FHML, Maastricht University, Duboisdomain 30 6229 GT Maastricht, The Netherlands. Electronic address:
Background: Fertility preservation (FP) is an important aspect of cancer care for male patients of reproductive age; however, there is a lack of research on male experiences of FP. This scoping review aims to identify barriers and facilitators to FP among male cancer patients, based on both patient and healthcare provider/researcher perspectives.
Method: We conducted a scoping review following the Joanna Briggs Institute methodology and reported results according to the PRISMA-ScR checklist.
J Obstet Gynaecol Can
August 2025
Department of Obstetrics and Gynaecology, University of Toronto, Temerty Faculty of Medicine, Toronto, Ontario, Canada; Mount Sinai Fertility, Mount Sinai Hospital, Toronto, Ontario, Canada. Electronic address:
Purpose: To assess perspectives of patients referred for urgent oncofertility consultation influencing whether to proceed or decline fertility preservation (FP).
Methods: An online survey was conducted in newly diagnosed cancer patients from August 2021 to July 2023 after an oncofertility consultation. Post-pubertal people with ovaries, a recent cancer diagnosis, and those who were referred for urgent oncofertility preservation consultation were eligible.