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Neural activity prior to movement onset contains essential information for predictive assistance for humans using brain-machine-interfaces (BMIs). Even though previous studies successfully predicted different goals for upcoming movements, it is unclear whether non-invasive recording signals contain the information to predict trial-by-trial behavioral variability under the same movement. In this paper, we examined the predictability of subsequent short or long reaction times (RTs) from magnetoencephalography (MEG) signals in a delayed-reach task. The difference in RTs was classified significantly above chance from 550 ms before the go-signal onset using the cortical currents in the premotor cortex. Significantly above-chance classification was performed in the lateral prefrontal and the right inferior parietal cortices at the late stage of the delay period. Thus, inter-trial variability in RTs is predictable information. Our study provides a proof-of-concept of the future development of non-invasive BMIs to prevent delayed movements.
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http://dx.doi.org/10.1038/srep27416 | DOI Listing |
J Neural Eng
September 2025
Department of Computer Science and Engineering College of Engineering, University of Washington, Box 352350, Seattle, WA 98195-2350, USA, Seattle, Washington, 98105, UNITED STATES.
Unlabelled: Closed-loop neural stimulation provides novel therapies for neurological diseases such as Parkinson's disease (PD), but it is not yet clear whether artificial intelligence (AI) techniques can tailor closed-loop stimulation to individual patients or identify new therapies. Further advancements are required to address a number of difficulties with translating AI to this domain, including sample efficiency, training time, and minimizing loop latency such that stimulation may be shaped in response to changing brain activity.
Approach: we propose temporal basis function models (TBFMs) to address these difficulties, and explore this approach in the context of excitatory optogenetic stimulation.
Dopaminergic neurons modulate movement, motivation, and learning by dynamically regulating dopamine release across distributed neural circuits. However, existing genetically encoded dopamine sensors lack the sensitivity and resolution to capture the full amplitude and temporal complexity of in vivo dopamine signaling, limiting insight into its functions across behavioral contexts. Here, we present dLight3.
View Article and Find Full Text PDFJ Cyst Fibros
August 2025
Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Augustenburger Platz 1, 13353 Berlin, Germany; German Center for Lung Research (DZL), associ
Background: Pulmonary function tests play an important role in diagnosis, management and treatment of people with cystic fibrosis (pwCF). Multiple-breath washout (MBW) is a sensitive method to detect ventilation inhomogeneities and is established in children with CF. Despite promising data in adults with pulmonary diseases, its feasibility remains questioned in adults due to longer examination times and limited added value over spirometry.
View Article and Find Full Text PDFImaging Neurosci (Camb)
February 2025
Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.
The auditory mismatch negativity (MMN) has been widely used to investigate deficits in early auditory information processing, particularly in psychosis. Predictive coding theories suggest that impairments in sensory learning may arise from disturbances in hierarchical message passing, likely due to aberrant precision-weighting of prediction errors (PEs). This study employed a modified auditory oddball paradigm with varying phases of stability and volatility to disentangle the impact of hierarchical PEs on auditory MMN generation in 43 healthy controls (HCs).
View Article and Find Full Text PDFImaging Neurosci (Camb)
October 2024
Experimental Psychology and Methods, Faculty of Life Sciences, Wilhelm-Wundt Institute for Psychology, Universität Leipzig, Leipzig, Germany.
Spatial attention is a key function enabling the selection of relevantinformation and meaningful behavioral responses and is likely implemented bydifferent neural mechanisms. In previous work, attention led to robust butuncorrelated modulations of Steady-State-Visual-Evoked-Potentials (SSVEPs) as amarker of early sensory gain and visual as well as motor alpha-band activity. Weprobed the behavioral relevance of attention-modulated trial-by-trialfluctuations of these measures.
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