Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Panallergens comprise various protein families of plant as well as animal origin and are responsible for wide IgE cross-reactivity between related and unrelated allergenic sources. Such cross-reactivities include reactions between various pollen sources, pollen and plant-derived foods as well as invertebrate-derived inhalants and foodstuff. Here, we provide an overview on the most clinically relevant panallergens from plants (profilins, polcalcins, non-specific lipid transfer proteins, pathogenesis-related protein family 10 members) and on the prominent animal-derived panallergen family, tropomyosins. In addition, we explore the role of panallergens in the sensitization process and progress of the allergic disease. Emphasis is given on epidemiological aspects of panallergen sensitization and clinical manifestations. Finally, the issues related to diagnosis and therapy of patients sensitized to panallergens are outlined, and the use of panallergens as predictors for cross-reactive allergy and as biomarkers for disease severity is discussed.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006871 | PMC |
| http://dx.doi.org/10.1111/pai.12589 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Association of allergen stability and epithelial barrier function in sensitized patients.
J Dtsch Dermatol Ges
August 2025
Department of Dermatology and Allergology, University Hospital of the Paracelsus Medical University, Salzburg, Austria.
Background And Objectives: Panallergen families differ in their stability to heat and pH, which affects both the severity and clinical manifestations of allergic reactions. The extent of epithelial barrier dysfunction is thought to influence sensitization to different allergens. This study aimed to investigate associations between patient characteristics, epithelial barrier-related markers, and distinct sensitization profiles.
View Article and Find Full Text PDFPatterns and Prevalence of Food Allergen Cross-Reactivity: A Cross-Sectional Study of Food-Allergic Adults in the Makkah Region, Saudi Arabia.
Cureus
April 2025
Department of Haematology and Immunology, College of Medicine, Umm Al-Qura University, Makkah, SAU.
Background And Objectives: Food allergies are a growing public health concern, with cross-reactivity complicating diagnosis and management. Cross-reactivity occurs when immune responses to one allergen trigger reactions to similar proteins in other allergens. There is a lack of regional data on the prevalence and patterns of food allergen cross-reactivity in Saudi Arabia, particularly in the Makkah region.
View Article and Find Full Text PDFThe Allergy Crossroads of Subtropical Regions: Mites, Crustaceans, and the Rise of Edible Insects.
Nutrients
April 2025
Allergy Department, Hospital Universitario de Canarias, 38320 Santa Cruz de Tenerife, Spain.
Edible insects (EIs) are increasingly recognized as a sustainable protein source, yet concerns persist regarding allergic reactions, even in individuals without prior known consumption. This study examines the immune response profile in patients from a subtropical area to improve understanding of mite-related cross-reactivity and emerging food sensitizations. To assess sensitization to edible insects, we analyzed 634 patients from a tertiary care allergy institution with high perennial exposure to house dust mites and storage mites.
View Article and Find Full Text PDFAllergic Potential of Medicinal Plants From the Asteraceae Family.
Health Sci Rep
February 2025
The Department of Pharmaceutical Biology, Faculty of Pharmacy University of Ljubljana Ljubljana Slovenia.
Background And Aims: The popularity of herbal medicine continues to increase in modern health care practices; therefore, it is imperative to recognize and address potential risks associated with its everyday use. The Asteraceae family is one of the most extensively utilized medicinal plant families due to its abundance and diversity of bioactive secondary metabolites. The aim of this article is to review the current understanding of the allergic potential of the most significant medicinal plant species belonging to the Asteraceae family.
View Article and Find Full Text PDFMolecular allergy diagnosis enabling personalized medicine.
J Allergy Clin Immunol
September 2025
Institute of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria; Department of Clinical Immunology and Allergy, Laboratory of Immunopathology, Sechenov First Moscow State Medical University, Moscow, Russia; Kar
Allergic patients are characterized by complex and patient-specific IgE sensitization profiles to various allergens, which are accompanied by different phenotypes of allergic disease. Molecular allergy diagnosis establishes the patient's IgE reactivity profile at a molecular allergen level and has moved allergology into the era of precision medicine. Molecular allergology started in the late 1980s with the isolation of the first allergen-encoding DNA sequences.
View Article and Find Full Text PDF