Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Streptococcus pyogenes is an important global pathogen, causing considerable morbidity and mortality, especially in low and middle income countries where rheumatic heart disease and invasive infections are common. There is a number of promising vaccine candidates, most notably those based on the M protein, the key virulence factor for the bacterium. Vaccines against Streptococcus pyogenes are considered as impeded vaccines because of a number of crucial barriers to development. Considerable effort is needed by key players to bring current vaccine candidates through phase III clinical trials and there is a clear need to develop a roadmap for future development of current and new candidates.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.vaccine.2016.03.073 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Streptococcus pyogenes EVs induce the alternative inflammasome via caspase-4/-5 in human monocytes.
EMBO Rep
September 2025
Max Planck Unit for the Science of Pathogens, Berlin, D-10117, Germany.
The sensing of Gram-negative Extracellular Vesicles (EVs) by the innate immune system has been extensively studied in the past decade. In contrast, recognition of Gram-positive EVs by innate immune cells remains poorly understood. Comparative genome-wide transcriptional analysis in human monocytes uncovered that S.
View Article and Find Full Text PDFFirst use of imlifidase desensitization in a highly sensitized heart and liver transplant candidate: A case report.
Hum Immunol
September 2025
Division of Cardiovascular Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.
Heart transplant candidates that are highly sensitized against human leukocyte antigens (HLA) face ongoing challenge in finding immunologically compatible donors. Desensitization strategies aimed at reducing HLA antibody titers have variable success rates. Imlifidase, a novel immunoglobulin G-degrading enzyme derived from Streptococcus pyogenes has been successfully used to eliminate pre-formed antibodies in sensitized kidney transplant recipients.
View Article and Find Full Text PDFA fatal pediatric case of meningitis and streptococcal toxic shock syndrome caused by emm12 Streptococcus pyogenes strain in Jiangsu, China, 2024.
Infection
September 2025
Department of Laboratory Medicine, Minhang Hospital, Fudan University, Shanghai, China.
A 23-month-old boy was admitted to our hospital with onset of fever and paroxysmal cough but progressed to death on Day 9. Streptococcus pyogenes was positive in cerebrospinal fluid and blood by next-generation sequencing, and was cultured from sputum. The isolate was resistant to erythromycin, clindamycin, and tetracycline.
View Article and Find Full Text PDFAn interaction between the transmembrane domains of sortase A and its endogenous substrate M protein revealed by molecular dynamics simulations.
bioRxiv
August 2025
Department of Chemistry, Western Washington University, Bellingham, WA, USA.
Sortase enzymes are cysteine transpeptidases at the cell surface of gram-positive bacteria. Localized to distinct foci on the cell membrane, class A sortases (SrtAs) recognize a cell wall sorting signal (CWSS), and following cleavage at this specific binding motif, target proteins are ligated to precursors of the growing peptidoglycan layer. This activity of SrtA enzymes is utilized extensively in sortase-mediated ligation (SML) strategies, for a variety of protein engineering applications.
View Article and Find Full Text PDFInfection and Drug Associated Tubulointerstitial Nephritis and Acute Tubular Necrosis in a Presentation Similar to That of Post-Streptococcal Glomerulonephritis: A Case Report.
J Investig Med High Impact Case Rep
September 2025
Eisenhower Medical Center, Rancho Mirage, CA, USA.
Tubulointerstitial nephritis (TIN) is an inflammatory infiltrate of interstitial kidney most commonly caused by infections, drugs, allergies, and a number of autoimmune conditions. In this case, we have a 40-year-old male who was thought to have post-streptococcal glomerulonephritis given his symptoms of sore throat and pharyngitis before having renal involvement; however, after further evaluation was found to have biopsy proven interstitial nephritis without glomerular involvement. We note that TIN has multiple etiologies, and in our patient, we believe the combination of sore throat and pharyngitis attributed to and the concomitant nonsteroidal anti-inflammatory drug use and eventual bacterial translocation into the bloodstream, led to all the atypical manifestations described in this study.
View Article and Find Full Text PDF