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Background: Tumours of the spinal cord, spinal meninges and cauda equina are relatively rare and their spectrum has not been studied extensively in Khyber Pakhtun Khawa province. We describe here the cases of spinal tumours treated in our setup over a period of two years.
Methods: This Descriptive Case Series was carried out with of 80 patients operated in our centre from January 2013 to January 2015. The clinical presentation of these tumours as well as demographic findings was analysed. Patients who underwent surgery for their tumours were included in the study. Patients were selected for surgery depending on their radiological and clinical findings. Lesions that were suggestive of metastasis were biopsied and further care was shared between specialized departments depending on the primary source.
Results: Male to female ratio was 1.5:1. Most of the spinal tumours were secondary tumours while meningiomas were the most common primary tumours. Most commonly patients belonged to young age group A (below 30 years.) 32.5%. Most common presentation was with paraparesis (27.5%) and paralysis (25%). A majority of patients regained good neurological function and did not show signs of recurrence at 1 year follow up.
Conclusion: Given the limited experience at our centre, we believe that a wide range of spinal tumours can be successfully treated provided that clinical end points are kept in mind and treatment is individualized. Frankel grading is useful to assess surgical outcome in the patients.
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Neuropathology
October 2025
Pathology Department, Complejo Hospitalario Universitario de Toledo, Toledo, Spain.
Glioblastoma (GB), IDH-wildtype (IDH-wt), is the most prevalent primary malignant brain neoplasm in adults. Despite adjuvant therapy, the prognosis for these tumors remains dismal, with a median survival of around 15-18 months. Although rare, extracranial metastases from GB are reported with increasing frequency, likely due to advancements in follow-up, treatments, and improved patient survival.
View Article and Find Full Text PDFCarbohydr Polym
November 2025
Engineering Technology Research Center of Drug Carrier of Guangdong, Department of Biomedical Engineering, Jinan University, Guangzhou 510632, China; Guangdong Provincial Key Laboratory of Spine and Spinal Cord Reconstruction, The Fifth Affiliated Hospital (Heyuan Shenhe People's Hospital), Jinan Un
Recently, a variety of stimulus-responsive hydrogel platforms have been developed, specifically designed to respond to changes in physiological signals within the disease microenvironment. However, due to the restricted regulation of drug release behavior in vivo by such hydrogel systems, the precise control of drug release kinetics has not been achieved. Therefore, developing precise drug delivery platforms that enable programmable and "on-off" delivery remains a challenge in this field.
View Article and Find Full Text PDFCureus
August 2025
Spine Surgery, National Institute of Neurology and Neurosurgery "Manuel Velasco Suárez", Mexico City, MEX.
Background Spinal ependymomas are the most common intradural tumors in adults and frequently lead to progressive neurological decline due to spinal cord compression. They typically present with subacute symptoms. The 2016 WHO classification stratifies them by histological grade, with recent updates incorporating molecular features.
View Article and Find Full Text PDFEur Radiol Exp
September 2025
Gustave Roussy, UMR 9018-Metabolic and Systemic Aspects of Oncogenesis for New Therapeutic Approaches (METSY), Paris-Saclay University, 114 rue Edouard Vaillant, 94805, Villejuif, France.
Background: Electrochemotherapy (ECT) of vertebral metastasis is a new treatment option for metastasis that is not accessible to thermal ablation or radiotherapy. A numerical feasibility study has investigated the transpedicular approach for electrode insertion. We conducted a preclinical study to assess its safety.
View Article and Find Full Text PDFFront Oncol
August 2025
Department of Spinal Surgery, No. 1 Orthopedics Hospital of Chengdu, Chengdu, China.
Primary bone tumours remain among the most challenging indications in radiation oncology-not because of anatomical size or distribution, but because curative intent demands ablative dosing alongside stringent normal-tissue preservation. Over the past decade, the therapeutic landscape has shifted markedly. Proton and carbon-ion centres now report durable local control with acceptable late toxicity in unresectable sarcomas.
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